Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 In vitro antileishmanial activity of nicotinamide.

Literature DB >> 15673775

In vitro antileishmanial activity of nicotinamide.

D Sereno¹, A Monte Alegre, R Silvestre, B Vergnes, A Ouaissi.

Abstract

Our study represents the first report demonstrating the antileishmanial activity of nicotinamide (NAm), a form of vitamin B(3). A 5 mM concentration of NAm significantly inhibited the intracellular growth of Leishmania amastigotes and the NAD-dependent deacetylase activity carried by parasites overexpressing Leishmania major SIR2 (LmSIR2). However, the transgenic parasites were as susceptible as the wild-type parasites to NAm-induced cell growth arrest. Therefore, we conclude that NAm inhibits leishmanial growth and that overexpression of LmSIR2 does not overcome this inhibition. The mechanism of the inhibition is not defined but may include other in vivo targets. NAm may thus represent a new antileishmanial agent which could potentially be used in combination with other drugs during therapy.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2005 PMID： 15673775 PMCID： PMC547366 DOI： 10.1128/AAC.49.2.808-812.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

Review 1. Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging.

Authors: S Imai; F B Johnson; R A Marciniak; M McVey; P U Park; L Guarente
Journal: Cold Spring Harb Symp Quant Biol Date: 2000

2. Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes.

Authors: D Sereno; P Holzmuller; I Mangot; G Cuny; A Ouaissi; J L Lemesre
Journal: Antimicrob Agents Chemother Date: 2001-07 Impact factor: 5.191

3. Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication.

Authors: R Brun
Journal: Acta Trop Date: 1979-09 Impact factor: 3.112

4. Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death.

Authors: Baptiste Vergnes; Denis Sereno; Niloufar Madjidian-Sereno; Jean-Loup Lemesre; Ali Ouaissi
Journal: Gene Date: 2002-08-21 Impact factor: 3.688

5. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Authors: Kevin J Bitterman; Rozalyn M Anderson; Haim Y Cohen; Magda Latorre-Esteves; David A Sinclair
Journal: J Biol Chem Date: 2002-09-23 Impact factor: 5.157

6. Pharmacokinetics of nicotinamide in cancer patients treated with accelerated radiotherapy: the experience of the Co-operative Group of Radiotherapy of the European Organization for Research and Treatment of Cancer.

Authors: J Bernier; M R Stratford; J Denekamp; M F Dennis; S Bieri; F Hagen; O Kocagöncü; M Bolla; A Rojas
Journal: Radiother Oncol Date: 1998-08 Impact factor: 6.280

Review 7. The Sir2 family of protein deacetylases.

Authors: Gil Blander; Leonard Guarente
Journal: Annu Rev Biochem Date: 2004 Impact factor: 23.643

Review 8. Nicotinamide: an oral antimicrobial agent with activity against both Mycobacterium tuberculosis and human immunodeficiency virus.

Authors: Michael F Murray
Journal: Clin Infect Dis Date: 2003-01-31 Impact factor: 9.079

9. The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells.

Authors: Michael W McBurney; Xiaofeng Yang; Karen Jardine; Melissa Bieman; John Th'ng; Madeleine Lemieux
Journal: Mol Cancer Res Date: 2003-03 Impact factor: 5.852

Review 10. Sirtuins: Sir2-related NAD-dependent protein deacetylases.

Authors: Brian J North; Eric Verdin
Journal: Genome Biol Date: 2004-04-28 Impact factor: 13.583

14 in total

1. Structural analysis of trypanosomal sirtuin: an insight for selective drug design.

Authors: Simranjeet Kaur; Amol V Shivange; Nilanjan Roy
Journal: Mol Divers Date: 2009-04-29 Impact factor: 2.943

Review 2. Exploring NAD+ metabolism in host-pathogen interactions.

Authors: Inês Mesquita; Patrícia Varela; Ana Belinha; Joana Gaifem; Mireille Laforge; Baptiste Vergnes; Jérôme Estaquier; Ricardo Silvestre
Journal: Cell Mol Life Sci Date: 2015-12-30 Impact factor: 9.261

Review 3. Leishmaniasis treatment--a challenge that remains: a review.

Authors: Dilvani O Santos; Carlos E R Coutinho; Maria F Madeira; Carolina G Bottino; Rodrigo T Vieira; Samara B Nascimento; Alice Bernardino; Saulo C Bourguignon; Suzana Corte-Real; Rosa T Pinho; Carlos Rangel Rodrigues; Helena C Castro
Journal: Parasitol Res Date: 2008-06 Impact factor: 2.289

4. Nicotinamide inhibits the lysosomal cathepsin b-like protease and kills African trypanosomes.

Authors: Juan D Unciti-Broceta; José Maceira; Sonia Morales; Angélica García-Pérez; Manuel E Muñóz-Torres; Jose A Garcia-Salcedo
Journal: J Biol Chem Date: 2013-02-26 Impact factor: 5.157

5. Effect of C-peptide Alone or in Combination with Nicotinamide on Insulin Levels from Pancreatic Islets in Mouse.

Authors: Akram Ahangarpour; Fatemeh Ramezani Ali Akbari; Hadi Fathi Moghadam
Journal: Malays J Med Sci Date: 2016-01

Review 6. Visceral leishmaniasis: experimental models for drug discovery.

Authors: Suman Gupta
Journal: Indian J Med Res Date: 2011-01 Impact factor: 2.375

7. Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases.

Authors: Mehdi Ouaissi; Ali Ouaissi
Journal: J Biomed Biotechnol Date: 2006

8. Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.

Authors: Vanina A Campo
Journal: Int J Parasitol Drugs Drug Resist Date: 2016-12-21 Impact factor: 4.077

9. Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

Authors: Luís Gaspar; Ross P Coron; Paul KongThoo Lin; David M Costa; Begoña Perez-Cabezas; Joana Tavares; Meritxell Roura-Ferrer; Isbaal Ramos; Céline Ronin; Louise L Major; Fabrice Ciesielski; Iain K Pemberton; Jane MacDougall; Paola Ciapetti; Terry K Smith; Anabela Cordeiro-da-Silva
Journal: PLoS Negl Trop Dis Date: 2018-01-22

Review 10. Lysine acetylation: elucidating the components of an emerging global signaling pathway in trypanosomes.

Authors: Victoria Lucia Alonso; Esteban Carlos Serra
Journal: J Biomed Biotechnol Date: 2012-10-03