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Literature DB >> 15672552

Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazol-induced seizures in mice.

Atilla Ilhan¹, Mustafa Iraz, Ahmet Gurel, Ferah Armutcu, Omer Akyol.

Abstract

Since overexcitation of excitatory amino acid is an important mechanism in seizure genesis wherein free radicals have recently been suggested to play a critical role, we explored the effects of caffeic acid phenethyl ester (CAPE) administration in pentylenetetrazole (PTZ)-induced seizure in mice. CAPE prevents the oxidative damage in brain tissue induced by PTZ, scavenging reactive oxygen species (ROS). Our results demonstrate that CAPE treatment which prevents free radical production and ameliorates seizure severity may be useful at least as an adjunctive treatment of seizure disorders.

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Year: 2004 PMID： 15672552 DOI： 10.1007/s11064-004-7038-y

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

37 in total

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16 in total

1. Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction.

Authors: Manar A Nader
Journal: Inflammopharmacology Date: 2012-05-19 Impact factor: 4.473

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Journal: World J Gastroenterol Date: 2006-11-14 Impact factor: 5.742

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Authors: Ertugrul Uzar; Hasan Rifat Koyuncuoglu; Efkan Uz; H Ramazan Yilmaz; Suleyman Kutluhan; Serkan Kilbas; Fatih Gultekin
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4. Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice.

Authors: Shigeki Moriguchi; Ryo Inagaki; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
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5. Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways.

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Authors: Sumeyya Akyol; Veli Ugurcu; Aynur Altuntas; Rukiye Hasgul; Ozlem Cakmak; Omer Akyol
Journal: ScientificWorldJournal Date: 2014-06-03