Literature DB >> 15672549

Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies.

Pravat K Mandal1, Jay W Pettegrew.   

Abstract

Amyloid beta peptide (Abeta) is a small peptide present in normal cells and aggregated Abeta is the main constituent of the extracellular amyloid plaques found in Alzheimer's disease (AD) brain. Recent studies suggest that soluble Abeta oligomers are neurotoxic rather than amyloid fibrils found in amyloid plaques. This study using multidimensional NMR spectroscopy and circular dichroism (CD) provides the first direct evidence that alterations in membrane structure can trigger the conversion of soluble alpha-helical monomeric Abeta into oligomeric Abeta in a beta-sheet conformation.

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Year:  2004        PMID： 15672549     DOI： 10.1007/s11064-004-7035-1

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  28 in total

1.  Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes.

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Journal:  J Biol Chem       Date:  1999-06-25       Impact factor: 5.157

2.  Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.

Authors:  Rakez Kayed; Elizabeth Head; Jennifer L Thompson; Theresa M McIntire; Saskia C Milton; Carl W Cotman; Charles G Glabe
Journal:  Science       Date:  2003-04-18       Impact factor: 47.728

3.  The Xplor-NIH NMR molecular structure determination package.

Authors:  Charles D Schwieters; John J Kuszewski; Nico Tjandra; G Marius Clore
Journal:  J Magn Reson       Date:  2003-01       Impact factor: 2.229

4.  31P nuclear magnetic resonance study of the brain in Alzheimer's disease.

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Journal:  J Neuropathol Exp Neurol       Date:  1988-05       Impact factor: 3.685

5.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

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Journal:  J Biomol NMR       Date:  1995-11       Impact factor: 2.835

7.  Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions.

Authors:  J W Geddes; K Panchalingam; J N Keller; J W Pettegrew
Journal:  Neurobiol Aging       Date:  1997 May-Jun       Impact factor: 4.673

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Journal:  Biochim Biophys Acta       Date:  1979-09-21

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Journal:  Arch Neurol       Date:  1988-10

10.  Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

Authors:  Karie N Dahlgren; Arlene M Manelli; W Blaine Stine; Lorinda K Baker; Grant A Krafft; Mary Jo LaDu
Journal:  J Biol Chem       Date:  2002-06-10       Impact factor: 5.157
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  16 in total

Review 1.  Fluorescence spectroscopy of protein oligomerization in membranes.

Authors:  Galyna P Gorbenko
Journal:  J Fluoresc       Date:  2010-04-06       Impact factor: 2.217

2.  Alzheimer's disease: halothane induces Abeta peptide to oligomeric form--solution NMR studies.

Authors:  Pravat K Mandal; Jay W Pettegrew; Dennish W McKeag; Ratna Mandal
Journal:  Neurochem Res       Date:  2006-06-29       Impact factor: 3.996

3.  Measuring translational diffusion coefficients of peptides and proteins by PFG-NMR using band-selective RF pulses.

Authors:  Shenggen Yao; Daniel K Weber; Frances Separovic; David W Keizer
Journal:  Eur Biophys J       Date:  2014-05-14       Impact factor: 1.733

Review 4.  Cause and consequence of Aβ - Lipid interactions in Alzheimer disease pathogenesis.

Authors:  Vijayaraghavan Rangachari; Dexter N Dean; Pratip Rana; Ashwin Vaidya; Preetam Ghosh
Journal:  Biochim Biophys Acta Biomembr       Date:  2018-03-09       Impact factor: 3.747

Review 5.  Impact of a discordant helix on β-amyloid structure, aggregation ability and toxicity.

Authors:  Yi-Cheng Chen
Journal:  Eur Biophys J       Date:  2017-07-07       Impact factor: 1.733

6.  Models of membrane-bound Alzheimer's Abeta peptide assemblies.

Authors:  Yinon Shafrir; Stewart Durell; Nelson Arispe; H Robert Guy
Journal:  Proteins       Date:  2010-10-11

7.  Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.

Authors:  Georg Künze; Patrick Barré; Holger A Scheidt; Lars Thomas; David Eliezer; Daniel Huster
Journal:  Biochim Biophys Acta       Date:  2012-04-06

8.  Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR.

Authors:  Jin Zhang; Xiaoguang Qu; Manuel Covarrubias; Markus W Germann
Journal:  Biochim Biophys Acta       Date:  2012-09-29

9.  Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments.

Authors:  Montserrat Serra-Batiste; Martí Ninot-Pedrosa; Mariam Bayoumi; Margarida Gairí; Giovanni Maglia; Natàlia Carulla
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-12       Impact factor: 11.205

10.  Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy.

Authors:  Ravi Prakash Reddy Nanga; Jeffrey R Brender; Jiadi Xu; Kevin Hartman; Vivekanandan Subramanian; Ayyalusamy Ramamoorthy
Journal:  J Am Chem Soc       Date:  2009-06-17       Impact factor: 15.419
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