Literature DB >> 15671576

Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly.

Fei Wang1, Paul Ruther, Ivy Jiang, Ritsuko Sawada-Hirai, Shu Man Sun, Rebecca Nedellec, Phillip R Morrow, Angray S Kang.   

Abstract

A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non-overlapping linear epitopes. Two of the antibodies neutralized the anthrax toxin by completely inhibiting the protective antigen oligomer assembly process in vitro.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15671576

Source DB:  PubMed          Journal:  Hum Antibodies        ISSN： 1093-2607


  18 in total

1.  Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge.

Authors:  Sherry R Crowe; Linda L Ash; Renata J M Engler; Jimmy D Ballard; John B Harley; A Darise Farris; Judith A James
Journal:  J Infect Dis       Date:  2010-07-15       Impact factor: 5.226

2.  A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model.

Authors:  Mahtab Moayeri; Clinton E Leysath; Jacqueline M Tremblay; Catherine Vrentas; Devorah Crown; Stephen H Leppla; Charles B Shoemaker
Journal:  J Biol Chem       Date:  2015-01-06       Impact factor: 5.157

3.  Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization.

Authors:  Kenneth Smith; Sherry R Crowe; Lori Garman; Carla J Guthridge; Jennifer J Muther; Emily McKee; Nai-Ying Zheng; A Darise Farris; Joel M Guthridge; Patrick C Wilson; Judith A James
Journal:  Vaccine       Date:  2012-03-14       Impact factor: 3.641

Review 4.  An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.

Authors:  Lernik Ohanjanian; Kenneth E Remy; Yan Li; Xizhong Cui; Peter Q Eichacker
Journal:  Expert Opin Investig Drugs       Date:  2015-04-28       Impact factor: 6.206

5.  Prophylaxis and therapy of inhalational anthrax by a novel monoclonal antibody to protective antigen that mimics vaccine-induced immunity.

Authors:  Laura Vitale; Diann Blanset; Israel Lowy; Thomas O'Neill; Joel Goldstein; Stephen F Little; Gerard P Andrews; Gary Dorough; Ronald K Taylor; Tibor Keler
Journal:  Infect Immun       Date:  2006-10       Impact factor: 3.441

6.  Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthrax.

Authors:  Johnny W Peterson; Jason E Comer; David M Noffsinger; Autumn Wenglikowski; Kristin G Walberg; Bagram M Chatuev; Ashok K Chopra; Lawrence R Stanberry; Angray S Kang; Wolfgang W Scholz; Jagadish Sircar
Journal:  Infect Immun       Date:  2006-02       Impact factor: 3.441

7.  Human monoclonal antibody AVP-21D9 to protective antigen reduces dissemination of the Bacillus anthracis Ames strain from the lungs in a rabbit model.

Authors:  Johnny W Peterson; Jason E Comer; Wallace B Baze; David M Noffsinger; Autumn Wenglikowski; Kristin G Walberg; Jason Hardcastle; Jennifer Pawlik; Kathryn Bush; Joanna Taormina; Scott Moen; John Thomas; Bagram M Chatuev; Laurie Sower; Ashok K Chopra; Lawrence R Stanberry; Ritsuko Sawada; Wolfgang W Scholz; Jagadish Sircar
Journal:  Infect Immun       Date:  2007-04-23       Impact factor: 3.441

8.  Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin.

Authors:  Bin Zhou; Charlotte Carney; Kim D Janda
Journal:  Bioorg Med Chem       Date:  2007-11-05       Impact factor: 3.641

9.  Characterization of a therapeutic model of inhalational anthrax using an increase in body temperature in New Zealand white rabbits as a trigger for treatment.

Authors:  Jason E Comer; Bryan D Ray; Lisa N Henning; Gregory V Stark; Roy E Barnewall; Jason M Mott; Gabriel T Meister
Journal:  Clin Vaccine Immunol       Date:  2012-07-25

Review 10.  Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.

Authors:  Anette Schneemann; Marianne Manchester
Journal:  Future Microbiol       Date:  2009-02       Impact factor: 3.165
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.