An animal model of Kaposi's sarcoma. II. Pathogenesis of dimethyl hydrazine induced angiosarcoma and colorectal cancer in three mouse strains.

CDI, C57B1/6 and DBA2 mice were subjected to dimethyl hydrazine (DMH) carcinogenesis to determine incidences of various types of tumors developing internally in the three strains. The animals were also screened for skin angiosarcomas. Skin lesions histologically similar to cutaneous AIDS associated Kaposi's sarcoma were observed in CD1 mice. Angiosarcomas predominated over colorectal tumors in C57Bl/6 and DBA2 mice, whereas the reverse was true for CD1 mice. The visceral angiosarcomas had both histological similarities and differences with visceral AIDS associated Kaposi's sarcoma.