Literature DB >> 15670896

RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women.

Livia Kelemen1, Amanda B Spurdle, David M Purdie, Dorota Gertig, Georgia Chenevix-Trench.   

Abstract

The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.

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Year:  2005        PMID： 15670896     DOI： 10.1016/j.canlet.2004.09.023

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  4 in total

1.  Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.

Authors:  Jonathan Beesley; Susan J Jordan; Amanda B Spurdle; Honglin Song; Susan J Ramus; Suzanne Kruger Kjaer; Estrid Hogdall; Richard A DiCioccio; Valerie McGuire; Alice S Whittemore; Simon A Gayther; Paul D P Pharoah; Penelope M Webb; Georgia Chenevix-Trench
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2007-12       Impact factor: 4.254

Review 2.  Role of genetic polymorphisms and ovarian cancer susceptibility.

Authors:  Peter A Fasching; Simon Gayther; Leigh Pearce; Joellen M Schildkraut; Ellen Goode; Falk Thiel; Georgia Chenevix-Trench; Jenny Chang-Claude; Shan Wang-Gohrke; Susan Ramus; Paul Pharoah; Andrew Berchuck
Journal:  Mol Oncol       Date:  2009-02-04       Impact factor: 6.603

3.  Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability.

Authors:  Jaime L Stafford; Gregory Dyson; Nancy K Levin; Sophia Chaudhry; Rita Rosati; Hasini Kalpage; Courtney Wernette; Nancie Petrucelli; Michael S Simon; Michael A Tainsky
Journal:  PLoS One       Date:  2017-06-07       Impact factor: 3.240

4.  BRCA2 N372H Polymorphism and Risk of Epithelial Ovarian Cancer: An Updated Meta-Analysis With 2344 Cases and 9672 Controls.

Authors:  Liangxiang Su; Jing Wang; Yumei Tao; Xuefeng Shao; Yiqian Ding; Xiaoyan Cheng; Ying Zhu
Journal:  Medicine (Baltimore)       Date:  2015-10       Impact factor: 1.817
  4 in total

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