Literature DB >> 15670842

Synergistic action of MLL, a TRX protein with template activating factor-I, a histone chaperone.

Tae Shimoyama1, Kohsuke Kato, Mary Miyaji-Yamaguchi, Kyosuke Nagata.   

Abstract

MLL is involved in the process of gene activity maintenance. It is shown that the amino-terminal region of MLL (MLLN) interacts with TAF-Ibeta/SET. In this study, using yeast two-hybrid assays, we have found that the acidic region of TAF-Ibeta is essential for its binding to MLLN. Pull-down assays using GST-MLLN demonstrated that TAF-Ibeta and histones interact with GST-MLLN. MLLN and TAF-Ibeta synergistically upregulated the transcription level of Hoxa9 and co-immunoprecipitated in chromatin containing the Hoxa9 promoter region. These results suggest that TAF-Ibeta plays an important role in MLL-mediated transcription and possibly chromatin maintenance.

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Year:  2005        PMID： 15670842     DOI： 10.1016/j.febslet.2004.12.064

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia.

Authors:  Pieter Van Vlierberghe; Martine van Grotel; Joëlle Tchinda; Charles Lee; H Berna Beverloo; Peter J van der Spek; Andrew Stubbs; Jan Cools; Kyosuke Nagata; Maarten Fornerod; Jessica Buijs-Gladdines; Martin Horstmann; Elisabeth R van Wering; Jean Soulier; Rob Pieters; Jules P P Meijerink
Journal:  Blood       Date:  2008-02-25       Impact factor: 22.113

2.  Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity.

Authors:  Kensaku Murano; Mitsuru Okuwaki; Miharu Hisaoka; Kyosuke Nagata
Journal:  Mol Cell Biol       Date:  2008-03-10       Impact factor: 4.272

3.  SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice.

Authors:  Ugur Ozbek; Ayten Kandilci; Sjozef van Baal; Jacqueline Bonten; Kelli Boyd; Patrick Franken; Riccardo Fodde; Gerard C Grosveld
Journal:  Am J Pathol       Date:  2007-06-14       Impact factor: 4.307

4.  Histone acetylation-independent transcription stimulation by a histone chaperone.

Authors:  Kohsuke Kato; Mary Miyaji-Yamaguchi; Mitsuru Okuwaki; Kyosuke Nagata
Journal:  Nucleic Acids Res       Date:  2006-12-19       Impact factor: 16.971

5.  A role for the nucleosome assembly proteins TAF-Iβ and NAP1 in the activation of BZLF1 expression and Epstein-Barr virus reactivation.

Authors:  Sheila Mansouri; Shan Wang; Lori Frappier
Journal:  PLoS One       Date:  2013-05-14       Impact factor: 3.240

Review 6.  A comprehensive and perspective view of oncoprotein SET in cancer.

Authors:  Buuvee Bayarkhangai; Suzan Noureldin; Liting Yu; Na Zhao; Yaru Gu; Hanmei Xu; Changying Guo
Journal:  Cancer Med       Date:  2018-05-10       Impact factor: 4.452

Review 7.  NUP214 in Leukemia: It's More than Transport.

Authors:  Adélia Mendes; Birthe Fahrenkrog
Journal:  Cells       Date:  2019-01-21       Impact factor: 6.600
  7 in total

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