Literature DB >> 15670820

A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution.

Vincenza Dolce1, Pasquale Scarcia, Domenico Iacopetta, Ferdinando Palmieri.   

Abstract

The mitochondrial ADP/ATP carriers (AACs) catalyze the exchange of cytosolic ADP for matrix ATP. We have identified and characterized a novel member of the AAC subfamily of mitochondrial metabolite transport proteins, termed AAC4. The AAC4 gene maps to human chromosome 4q28.1, and its product AAC4 is 66-68% identical to human AAC 1-3 and is localized to mitochondria. AAC4 transcripts are exclusively present in liver, testis and brain unlike those of AAC 1-3. Consistent with its belonging to the AAC subfamily, upon heterologous expression and reconstitution into liposomes AAC4 exchanges ADP for ATP by an electrogenic antiport mechanism with high specificity and high sensitivity to carboxyatractyloside and bongkrekic acid.

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Year:  2005        PMID： 15670820     DOI： 10.1016/j.febslet.2004.12.034

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  73 in total

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Journal:  Dev Biol       Date:  2006-10-10       Impact factor: 3.582

Review 2.  Physiological and pathological roles of mitochondrial SLC25 carriers.

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Journal:  Biochem J       Date:  2013-09-15       Impact factor: 3.857

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4.  Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.

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Authors:  Ilian A Radichev; Albert G Remacle; Nor Eddine Sounni; Sergey A Shiryaev; Dmitri V Rozanov; Wenhong Zhu; Natalya V Golubkova; Tatiana I Postnova; Vladislav S Golubkov; Alex Y Strongin
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6.  MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes.

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Journal:  J Biol Chem       Date:  2009-12-10       Impact factor: 5.157

7.  A conserved E2F6-binding element in murine meiosis-specific gene promoters.

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8.  Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction.

Authors:  M Chen; Y Zhang; V C Yu; Y-S Chong; T Yoshioka; R Ge
Journal:  Cell Death Differ       Date:  2014-01-24       Impact factor: 15.828

9.  Adenine nucleotide translocator as a regulator of mitochondrial function: implication in the pathogenesis of metabolic syndrome.

Authors:  Eun Hee Kim; Eun Hee Koh; Joong-Yeol Park; Ki-Up Lee
Journal:  Korean Diabetes J       Date:  2010-06-30

10.  A novel kinetic assay of mitochondrial ATP-ADP exchange rate mediated by the ANT.

Authors:  Christos Chinopoulos; Szilvia Vajda; László Csanády; Miklós Mándi; Katalin Mathe; Vera Adam-Vizi
Journal:  Biophys J       Date:  2009-03-18       Impact factor: 4.033
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