| Literature DB >> 15670782 |
Keiichi Hishikawa1, Takeshi Marumo, Shigeki Miura, Asato Nakanishi, Yumi Matsuzaki, Katsunori Shibata, Hiroko Kohike, Takuya Komori, Matsuhiko Hayashi, Toshio Nakaki, Hiromitsu Nakauchi, Hideyuki Okano, Toshiro Fujita.
Abstract
Side population (SP) is reported to be a stem cell-rich population. In the presence of leukemia inhibitory factor (LIF), cultured kidney SP cells differentiated into multi-lineage in collagen gel but not in synthesized polymer that has no cell adhesion factor. In cultured kidney SP cells, gene expression of kidney-specific cadherin 16 was specifically upregulated in collagen gel but not in synthesized polymer. Moreover, decreasing cadherin 16 expression using siRNA abolished LIF-induced multi-lineage differentiation of kidney SP in collagen gel. These results indicated that LIF induced multi-lineage differentiation of adult stem-like cells in kidney via cadherin 16.Entities:
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Year: 2005 PMID： 15670782 DOI： 10.1016/j.bbrc.2004.12.167
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575