Literature DB >> 15669826

Photoinduced switch of a DNA/RNA inactive molecule into a classical intercalator.

Kristina Starcević1, Grace Karminski-Zamola, Ivo Piantanida, Mladen Zinić, Lidija Suman, Marijeta Kralj.   

Abstract

Spectroscopic titrations and thermal denaturation experiments show that "acyclic" analogue 1 does not bind to ds-DNA, but under same conditions "cyclic" 2 strongly interacts with ds-DNA and ds-RNA by intercalation into the double helix. Besides, 2 is significantly more effective in inhibition of the tumor cell growth in vitro than 1. We have shown that it is possible to efficiently and irreversibly convert "DNA inactive" compound 1 into "DNA active" compound 2 by light irradiation of the aqueous solutions of the former. This strategy offers a new and attractive approach to photoinduced anticancer therapy.

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Year:  2005        PMID： 15669826     DOI： 10.1021/ja0438866

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  5 in total

1.  Spiropyran as a potential molecular diagnostic tool for double-stranded RNA detection.

Authors:  Ahsan Ausaf Ali; Minjeong Kang; Raisa Kharbash; Yoosik Kim
Journal:  BMC Biomed Eng       Date:  2019-03-18

2.  Synthesis of novel benzimidazolyl-substituted acrylonitriles and amidino-substituted benzimidazo[1,2-a]quinolines.

Authors:  Marijana Hranjec; Grace Karminski-Zamola
Journal:  Molecules       Date:  2006-08-13       Impact factor: 4.411

3.  Novel synthesis and antitumor evaluation of polyfunctionally substituted heterocyclic compounds derived from 2-cyano-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-acetamide.

Authors:  Hoda Z Shams; Rafat M Mohareb; Maher H Helal; Amira E Mahmoud
Journal:  Molecules       Date:  2010-12-27       Impact factor: 4.411

4.  Bis(phenylethynyl)arene Linkers in Tetracationic Bis-triarylborane Chromophores Control Fluorimetric and Raman Sensing of Various DNAs and RNAs.

Authors:  Matthias Ferger; Željka Ban; Ivona Krošl; Sanja Tomić; Lena Dietrich; Sabine Lorenzen; Florian Rauch; Daniel Sieh; Alexandra Friedrich; Stefanie Griesbeck; Adriana Kenđel; Snežana Miljanić; Ivo Piantanida; Todd B Marder
Journal:  Chemistry       Date:  2021-02-24       Impact factor: 5.236

5.  Bis-Pyrene Photo-Switch Open- and Closed-Form Differently Bind to ds-DNA, ds-RNA and Serum Albumin and Reveal Light-Induced Bioactivity.

Authors:  Iva Orehovec; Marija Matković; Isabela Pehar; Dragomira Majhen; Ivo Piantanida
Journal:  Int J Mol Sci       Date:  2021-05-06       Impact factor: 5.923
  5 in total

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