Interactions between viruses in transplant recipients.

Viral coinfections may modulate disease expression, enhance pathogenicity, and lead to greater cumulative immunosuppression in the host. The pathophysiological basis of these may be direct virus-virus interactions, effect of cohabitating viruses on host cell function, or impaired host immune responses. The interrelationship between viral pathogens has become increasingly more relevant and its scope wider as new or previously unrecognized viruses continue to emerge as pathogens in transplant recipients. The pathways and mediators that modulate biological activity represent potential targets for immunomodulatory interventions as adjunctive therapies for transplant recipients.