| Literature DB >> 15668448 |
T Edwards-Lee1, J M Ringman, J Chung, J Werner, A Morgan, P St George Hyslop, P Thompson, R Dutton, A Mlikotic, E Rogaeva, J Hardy.
Abstract
The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease. The clinical characteristics were an unusually early onset of disease (early 30s), similar to a previously reported age at onset of this mutation in an Austrian family. Distinct from that family, seizures and myoclonus were prominent features of the disease in this kindred.Entities:
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Year: 2005 PMID： 15668448 DOI： 10.1212/01.WNL.0000149761.70566.3E
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910