Literature DB >> 15668438

Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation.

K Asanuma1, Y Ma, J Okulski, V Dhawan, T Chaly, M Carbon, S B Bressman, D Eidelberg.   

Abstract

To determine whether reduced striatal D2 receptor binding reported in patients with idiopathic torsion dystonia is associated with the genotype, the authors used PET and [11C]-raclopride to assess non-manifesting carriers of the DYT1 mutation. D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype.

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Year:  2005        PMID： 15668438     DOI： 10.1212/01.WNL.0000149764.34953.BF

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  62 in total

Review 1.  Genetic and clinical features of primary torsion dystonia.

Authors:  Laurie J Ozelius; Susan B Bressman
Journal:  Neurobiol Dis       Date:  2010-12-17       Impact factor: 5.996

2.  Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia.

Authors:  Kristina Simonyan; Brian D Berman; Peter Herscovitch; Mark Hallett
Journal:  J Neurosci       Date:  2013-09-11       Impact factor: 6.167

3.  Increased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study.

Authors:  Maren Carbon; Maria Felice Ghilardi; Miklos Argyelan; Vijay Dhawan; Susan B Bressman; David Eidelberg
Journal:  Brain       Date:  2007-10-18       Impact factor: 13.501

4.  Single unit "pauser" characteristics of the globus pallidus pars externa distinguish primary dystonia from secondary dystonia and Parkinson's disease.

Authors:  Sepehr Sani; Jill L Ostrem; Shoichi Shimamoto; Nadja Levesque; Philip A Starr
Journal:  Exp Neurol       Date:  2008-12-24       Impact factor: 5.330

Review 5.  Engineering animal models of dystonia.

Authors:  Janneth Oleas; Fumiaki Yokoi; Mark P DeAndrade; Antonio Pisani; Yuqing Li
Journal:  Mov Disord       Date:  2013-06-15       Impact factor: 10.338

6.  Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice.

Authors:  Fumiaki Yokoi; Janneth Oleas; Hong Xing; Yuning Liu; Kelly M Dexter; Carly Misztal; Melinda Gerard; Iakov Efimenko; Patrick Lynch; Matthew Villanueva; Raul Alsina; Shiv Krishnaswamy; David E Vaillancourt; Yuqing Li
Journal:  Neurobiol Dis       Date:  2019-10-13       Impact factor: 5.996

Review 7.  Primary dystonia: molecules and mechanisms.

Authors:  Lauren M Tanabe; Connie E Kim; Noga Alagem; William T Dauer
Journal:  Nat Rev Neurol       Date:  2009-10-13       Impact factor: 42.937

Review 8.  Task-specific dystonias: a review.

Authors:  Diego Torres-Russotto; Joel S Perlmutter
Journal:  Ann N Y Acad Sci       Date:  2008-10       Impact factor: 5.691

9.  Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.

Authors:  Anthony M Downs; Xueliang Fan; Christine Donsante; H A Jinnah; Ellen J Hess
Journal:  Neurobiol Dis       Date:  2019-01-30       Impact factor: 5.996

10.  Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia.

Authors:  Giuseppe Sciamanna; Paola Bonsi; Annalisa Tassone; Dario Cuomo; Anne Tscherter; Maria Teresa Viscomi; Giuseppina Martella; Nutan Sharma; Giorgio Bernardi; David G Standaert; Antonio Pisani
Journal:  Neurobiol Dis       Date:  2009-01-13       Impact factor: 5.996
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