| Literature DB >> 15668334 |
N S Treister1, S M Richards, M J Lombardi, P Rowley, R V Jensen, D A Sullivan.
Abstract
Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression between males and females. Glands were collected from male and female BALB/c mice (n = 5/sex/experiment), and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs with CodeLink microarrays, and data were evaluated by GeneSifter. Our results demonstrate that significant (P < 0.05) sex-related differences exist in the expression of numerous genes in the major salivary glands, and many of these differences were tissue-specific. These findings support our hypothesis that sex-related differences in the salivary glands are due, at least in part, to tissue-specific variations in gene expression.Entities:
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Year: 2005 PMID： 15668334 DOI： 10.1177/154405910508400210
Source DB: PubMed Journal: J Dent Res ISSN： 0022-0345 Impact factor: 6.116