BACKGROUND: In neoplastic head and neck lesions, it has been found that the loss or reduction in E-cadherin expression is a late event and is associated with invasion. Low p27 levels have been associated with a poor prognosis in many different tumors, including laryngeal carcinoma. The authors investigated p27 and E-cadherin protein expression in the early stages of head and neck tumorigenesis and evaluated their predictive roles individually and in association with carcinogenesis. METHODS: Tissue biopsies from 46 patients who were participants in 3 chemoprevention trials were analyzed for E-cadherin expression, and 40 samples were analyzed for p27 expression using immunohistochemistry. RESULTS: The data suggested that loss of both E-cadherin expression and p27 expression occurred early during the preneoplastic steps of head and neck carcinogenesis, and loss of p27 protein expression alone (P=0.02) and in combination with loss of E-cadherin expression (P=0.04) was a significant predictor of the risk for head and neck carcinoma. CONCLUSIONS: The loss of p27 expression may be useful in the construction of a risk model for head and neck carcinogenesis and may represent a potential target for chemopreventive interventions. Longer follow-up of the high percentage of low-risk preneoplastic lesions in the current study and validation in a larger sample size may be required to establish the predictive role of these abnormalities.
BACKGROUND: In neoplastic head and neck lesions, it has been found that the loss or reduction in E-cadherin expression is a late event and is associated with invasion. Low p27 levels have been associated with a poor prognosis in many different tumors, including laryngeal carcinoma. The authors investigated p27 and E-cadherin protein expression in the early stages of head and neck tumorigenesis and evaluated their predictive roles individually and in association with carcinogenesis. METHODS: Tissue biopsies from 46 patients who were participants in 3 chemoprevention trials were analyzed for E-cadherin expression, and 40 samples were analyzed for p27 expression using immunohistochemistry. RESULTS: The data suggested that loss of both E-cadherin expression and p27 expression occurred early during the preneoplastic steps of head and neck carcinogenesis, and loss of p27 protein expression alone (P=0.02) and in combination with loss of E-cadherin expression (P=0.04) was a significant predictor of the risk for head and neck carcinoma. CONCLUSIONS: The loss of p27 expression may be useful in the construction of a risk model for head and neck carcinogenesis and may represent a potential target for chemopreventive interventions. Longer follow-up of the high percentage of low-risk preneoplastic lesions in the current study and validation in a larger sample size may be required to establish the predictive role of these abnormalities.
Authors: Katja Kiseljak-Vassiliades; Mei Xu; Taylor S Mills; Elizabeth E Smith; Lori J Silveira; Kevin O Lillehei; Janice M Kerr; B K Kleinschmidt-DeMasters; Margaret E Wierman Journal: Mol Cell Endocrinol Date: 2015-09-21 Impact factor: 4.102
Authors: Alessandro Villa; Antonio Celentano; Ingrid Glurich; Wenche S Borgnakke; Siri Beier Jensen; Douglas E Peterson; Konstantina Delli; David Ojeda; Arjan Vissink; Camile S Farah Journal: Oral Dis Date: 2019-06 Impact factor: 3.511
Authors: H Galera-Ruiz; M J Ríos-Moreno; R González-Cámpora; I Ortega; A Fernández; A García-Escudero; H Galera-Davidson Journal: Eur Arch Otorhinolaryngol Date: 2011-12-25 Impact factor: 2.503
Authors: A Batistatou; C D Scopa; P Ravazoula; Y Nakanishi; D Peschos; N J Agnantis; S Hirohashi; K A Charalabopoulos Journal: Br J Cancer Date: 2005-12-12 Impact factor: 7.640
Authors: A Batistatou; D Peschos; H Tsanou; A Charalabopoulos; Y Nakanishi; S Hirohashi; N J Agnantis; K Charalabopoulos Journal: Br J Cancer Date: 2007-04-17 Impact factor: 7.640