Literature DB >> 1566583

Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R.

M Vey1, M Orlich, S Adler, H D Klenk, R Rott, W Garten.   

Abstract

The hemagglutinin of influenza virus A/FPV/Rostock/34 (H7) was altered at its multibasic cleavage site by site-directed mutagenesis and assayed for proteolytic activation after expression in CV-1 cells. The results indicated that the cellular protease responsible for activation recognizes the tetrapeptide motif R-X-K/R-R that must be presented in the correct sequence position. Studies on plaque variants of influenza virus A/fowl/Victoria/75 (H7N7) showed that alteration of the consensus sequence resulted in a loss of pathogenicity for chickens.

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Year:  1992        PMID： 1566583      PMCID： PMC7172898          DOI： 10.1016/0042-6822(92)90775-k

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  36 in total

1.  Analysis of the relationship between cleavability of a paramyxovirus fusion protein and length of the connecting peptide.

Authors:  R G Paterson; M A Shaughnessy; R A Lamb
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

2.  Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells.

Authors:  Y Kawaoka; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

3.  Sequence of the hemagglutinin gene from influenza virus A/Seal/Mass/1/80.

Authors:  C W Naeve; R G Webster
Journal:  Virology       Date:  1983-09       Impact factor: 3.616

4.  Nucleotide sequence of cdna coding for Semliki Forest virus membrane glycoproteins.

Authors:  H Garoff; A M Frischauf; K Simons; H Lehrach; H Delius
Journal:  Nature       Date:  1980-11-20       Impact factor: 49.962

5.  Mutations within the proteolytic cleavage site of the Rous sarcoma virus glycoprotein that block processing to gp85 and gp37.

Authors:  L G Perez; E Hunter
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

6.  Role of Staphylococcus protease in the development of influenza pneumonia.

Authors:  M Tashiro; P Ciborowski; H D Klenk; G Pulverer; R Rott
Journal:  Nature       Date:  1987 Feb 5-11       Impact factor: 49.962

7.  Molecular analysis of the hemagglutinin genes of Australian H7N7 influenza viruses: role of passerine birds in maintenance or transmission?

Authors:  A Nestorowicz; Y Kawaoka; W J Bean; R G Webster
Journal:  Virology       Date:  1987-10       Impact factor: 3.616

8.  Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus.

Authors:  J M McCune; L B Rabin; M B Feinberg; M Lieberman; J C Kosek; G R Reyes; I L Weissman
Journal:  Cell       Date:  1988-04-08       Impact factor: 41.582

9.  Intracellular targeting and structural conservation of a prohormone-processing endoprotease.

Authors:  R S Fuller; A J Brake; J Thorner
Journal:  Science       Date:  1989-10-27       Impact factor: 47.728

10.  Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41.

Authors:  D Cavanagh; P J Davis; D J Pappin; M M Binns; M E Boursnell; T D Brown
Journal:  Virus Res       Date:  1986-02       Impact factor: 3.303
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  49 in total

1.  Hemagglutinin of influenza virus partitions into the nonraft domain of model membranes.

Authors:  Jörg Nikolaus; Silvia Scolari; Elisa Bayraktarov; Nadine Jungnick; Stephanie Engel; Anna Pia Plazzo; Martin Stöckl; Rudolf Volkmer; Michael Veit; Andreas Herrmann
Journal:  Biophys J       Date:  2010-07-21       Impact factor: 4.033

2.  Cleavage of influenza A virus H1 hemagglutinin by swine respiratory bacterial proteases.

Authors:  R J Callan; F A Hartmann; S E West; V S Hinshaw
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

3.  Cross-reactive neutralizing antibodies directed against pandemic H1N1 2009 virus are protective in a highly sensitive DBA/2 mouse influenza model.

Authors:  Adrianus C M Boon; Jennifer deBeauchamp; Scott Krauss; Adam Rubrum; Ashley D Webb; Robert G Webster; Janet McElhaney; Richard J Webby
Journal:  J Virol       Date:  2010-05-19       Impact factor: 5.103

4.  Processing of the Ebola virus glycoprotein by the proprotein convertase furin.

Authors:  V E Volchkov; H Feldmann; V A Volchkova; H D Klenk
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-12       Impact factor: 11.205

5.  Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.

Authors:  Eva Böttcher-Friebertshäuser; David A Stein; Hans-Dieter Klenk; Wolfgang Garten
Journal:  J Virol       Date:  2010-12-01       Impact factor: 5.103

6.  Direct reverse transcriptase PCR to determine virulence potential of influenza A viruses in birds.

Authors:  T Horimoto; Y Kawaoka
Journal:  J Clin Microbiol       Date:  1995-03       Impact factor: 5.948

7.  A Unique Multibasic Proteolytic Cleavage Site and Three Mutations in the HA2 Domain Confer High Virulence of H7N1 Avian Influenza Virus in Chickens.

Authors:  El-Sayed M Abdelwhab; Jutta Veits; Kerstin Tauscher; Mario Ziller; Jens P Teifke; Jürgen Stech; Thomas C Mettenleiter
Journal:  J Virol       Date:  2015-10-21       Impact factor: 5.103

Review 8.  Human health implications of avian influenza viruses and paramyxoviruses.

Authors:  I Capua; D J Alexander
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-12-09       Impact factor: 3.267

9.  Full genome comparison and characterization of avian H10 viruses with different pathogenicity in Mink (Mustela vison) reveals genetic and functional differences in the non-structural gene.

Authors:  Siamak Zohari; Giorgi Metreveli; István Kiss; Sándor Belák; Mikael Berg
Journal:  Virol J       Date:  2010-06-30       Impact factor: 4.099

10.  Deduced amino acid sequences of the haemagglutinin of H5N1 avian influenza virus isolates from an outbreak in turkeys in Norfolk, England.

Authors:  G W Wood; J Banks; J W McCauley; D J Alexander
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574
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