Literature DB >> 1566581

Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes.

A de Ronde1, B Klaver, W Keulen, L Smit, J Goudsmit.   

Abstract

HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines.

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Year:  1992        PMID： 1566581     DOI： 10.1016/0042-6822(92)90772-h

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  72 in total

1.  A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.

Authors:  L Alexander; Z Du; M Rosenzweig; J U Jung; R C Desrosiers
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

Review 2.  Viral modulation of T-cell receptor signaling.

Authors:  Keith R Jerome
Journal:  J Virol       Date:  2008-02-20       Impact factor: 5.103

3.  Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell.

Authors:  O Schwartz; V Maréchal; O Danos; J M Heard
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

4.  Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

Authors:  S S Rhee; J W Marsh
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

5.  Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.

Authors:  C Aiken; D Trono
Journal:  J Virol       Date:  1995-08       Impact factor: 5.103

Review 6.  The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.

Authors:  S Bour; R Geleziunas; M A Wainberg
Journal:  Microbiol Rev       Date:  1995-03

7.  Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef.

Authors:  O Schwartz; Y Rivière; J M Heard; O Danos
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

8.  Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene.

Authors:  F Kirchhoff; H W Kestler; R C Desrosiers
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

9.  Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes.

Authors:  E T Sawai; A Baur; H Struble; B M Peterlin; J A Levy; C Cheng-Mayer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

10.  Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity.

Authors:  C Aiken
Journal:  Virology       Date:  1998-08-15       Impact factor: 3.616
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