OBJECTIVE: To characterize the lipid profile in Alzheimer's Disease (AD) and to determine whether it differs from the cardiac risk profile. BACKGROUND: Links between hypercholesterolemia and AD development continue to grow. Presently, limited information exists about the lipid profile characteristics in AD. METHODS: We examined the lipid profiles (total cholesterol (TC), high-density lipoprotein (HDL), lower-density lipoprotein (LDL), TC/HDL ratio, and triglyceride (TG) levels) of 153 subjects with probable/possible AD (mean age 77.2 +/- 8.6 years, mean MMSE 19.9 +/- 5.6) and 25 non-demented subjects with atherosclerotic heart disease (ASHD) (mean age 73.8 +/- 7.2 years); neither on lipid lowering therapy. RESULTS: Subjects with TC > 200 mg/dl composed 69% of AD and 72% of ASHD groups. Mean TC was 218.9 +/- 38.9 mg/dl and 218.5 +/- 9.2 mg/dl for AD and ASHD subjects respectively. AD subjects exhibited significantly higher HDL and lower TG and TC/HDL ratios. MMSE did not correlate with any lipid parameters in AD. DISCUSSION: Elevated TC, LDL and TG with normal HDL and TC/HDL ratio characterize the lipid profile in AD, which somewhat overlaps with but may be distinct from the cardiac risk profile. MMSE does not correlate with lipid parameters suggesting no interaction between cholesterol and cognition in AD.
OBJECTIVE: To characterize the lipid profile in Alzheimer's Disease (AD) and to determine whether it differs from the cardiac risk profile. BACKGROUND: Links between hypercholesterolemia and AD development continue to grow. Presently, limited information exists about the lipid profile characteristics in AD. METHODS: We examined the lipid profiles (total cholesterol (TC), high-density lipoprotein (HDL), lower-density lipoprotein (LDL), TC/HDL ratio, and triglyceride (TG) levels) of 153 subjects with probable/possible AD (mean age 77.2 +/- 8.6 years, mean MMSE 19.9 +/- 5.6) and 25 non-demented subjects with atherosclerotic heart disease (ASHD) (mean age 73.8 +/- 7.2 years); neither on lipid lowering therapy. RESULTS: Subjects with TC > 200 mg/dl composed 69% of AD and 72% of ASHD groups. Mean TC was 218.9 +/- 38.9 mg/dl and 218.5 +/- 9.2 mg/dl for AD and ASHD subjects respectively. AD subjects exhibited significantly higher HDL and lower TG and TC/HDL ratios. MMSE did not correlate with any lipid parameters in AD. DISCUSSION: Elevated TC, LDL and TG with normal HDL and TC/HDL ratio characterize the lipid profile in AD, which somewhat overlaps with but may be distinct from the cardiac risk profile. MMSE does not correlate with lipid parameters suggesting no interaction between cholesterol and cognition in AD.
Authors: Nikolett Lénárt; Viktor Szegedi; Gábor Juhász; Aniko Kasztner; János Horváth; Erika Bereczki; Melinda E Tóth; Botond Penke; Miklós Sántha Journal: PLoS One Date: 2012-09-24 Impact factor: 3.240
Authors: Carlos Ramírez; Saleta Sierra; Inmaculada Tercero; Jose Antonio Vázquez; Antonia Pineda; Tatiana Manrique; Javier S Burgos Journal: PLoS One Date: 2011-07-26 Impact factor: 3.240
Authors: Nikolett Lénárt; Fruzsina R Walter; Alexandra Bocsik; Petra Sántha; Melinda E Tóth; András Harazin; Andrea E Tóth; Csaba Vizler; Zsolt Török; Ana-Maria Pilbat; László Vígh; László G Puskás; Miklós Sántha; Mária A Deli Journal: Fluids Barriers CNS Date: 2015-07-17
Authors: Seul Kee Byeon; Anil K Madugundu; Ankit P Jain; Firdous A Bhat; Jae Hun Jung; Santosh Renuse; Jacqueline Darrow; Arnold Bakker; Marilyn Albert; Abhay Moghekar; Akhilesh Pandey Journal: Mol Omics Date: 2021-06-14