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Literature DB >> 15664968

Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus.

Helen J Wing¹, Seth R Goldman, Shabeen Ally, Marcia B Goldberg.

Abstract

The Shigella actin assembly protein IcsA is removed from the bacterial surface by the protease IcsP. We show that decreased intracellular spreading of virK::Tn10 mutants is due in part to significant increases in IcsP and IcsP-mediated cleavage of IcsA and that IcsP expression is a critical determinant of Shigella virulence.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15664968 PMCID： PMC547015 DOI： 10.1128/IAI.73.2.1217-1220.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

30 in total

1. Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.

Authors: L Vandeputte-Rutten; R A Kramer; J Kroon; N Dekker; M R Egmond; P Gros
Journal: EMBO J Date: 2001-09-17 Impact factor: 11.598

2. Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide.

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Journal: Science Date: 1998-12-18 Impact factor: 47.728

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Journal: Gene Date: 1986 Impact factor: 3.688

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Authors: H Ogawa; A Nakamura; R Nakaya
Journal: Jpn J Med Sci Biol Date: 1968-08

5. The unipolar Shigella surface protein IcsA is targeted directly to the bacterial old pole: IcsP cleavage of IcsA occurs over the entire bacterial surface.

Authors: J Steinhauer; R Agha; T Pham; A W Varga; M B Goldberg
Journal: Mol Microbiol Date: 1999-04 Impact factor: 3.501

6. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

Authors: M L Bernardini; J Mounier; H d'Hauteville; M Coquis-Rondon; P J Sansonetti
Journal: Proc Natl Acad Sci U S A Date: 1989-05 Impact factor: 11.205

7. Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica.

Authors: Maini Kukkonen; Marjo Suomalainen; Päivi Kyllönen; Kaarina Lähteenmäki; Hannu Lång; Ritva Virkola; Ilkka M Helander; Otto Holst; Timo K Korhonen
Journal: Mol Microbiol Date: 2004-01 Impact factor: 3.501

8. Bacteriophage Mu d1(Apr lac) generates vir-lac operon fusions in Shigella flexneri 2a.

Authors: A T Maurelli; R Curtiss
Journal: Infect Immun Date: 1984-09 Impact factor: 3.441

9. Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement.

Authors: M B Goldberg; O Bârzu; C Parsot; P J Sansonetti
Journal: J Bacteriol Date: 1993-04 Impact factor: 3.490

10. Identification and characterization of virK, a virulence-associated large plasmid gene essential for intercellular spreading of Shigella flexneri.

Authors: N Nakata; C Sasakawa; N Okada; T Tobe; I Fukuda; T Suzuki; K Komatsu; M Yoshikawa
Journal: Mol Microbiol Date: 1992-08 Impact factor: 3.501

11 in total

1. Salmonella enterica serovar enteritidis antimicrobial peptide resistance genes aid in defense against chicken innate immunity, fecal shedding, and egg deposition.

Authors: Jessica A McKelvey; Ming Yang; Yanhua Jiang; Shuping Zhang
Journal: Infect Immun Date: 2014-09-29 Impact factor: 3.441

2. Two promoters and two translation start sites control the expression of the Shigella flexneri outer membrane protease IcsP.

Authors: Christopher T Hensley; Olga K Kamneva; Karen M Levy; Stephanie K Labahn; Lia A Africa; Helen J Wing
Journal: Arch Microbiol Date: 2011-01-12 Impact factor: 2.552

3. The iron-responsive Fur/RyhB regulatory cascade modulates the Shigella outer membrane protease IcsP.

Authors: Lia A A Africa; Erin R Murphy; Nicholas R Egan; Amanda F Wigley; Helen J Wing
Journal: Infect Immun Date: 2011-08-22 Impact factor: 3.441

4. VirK is a periplasmic protein required for efficient secretion of plasmid-encoded toxin from enteroaggregative Escherichia coli.

Authors: Gabriela Tapia-Pastrana; Lucia Chavez-Dueñas; Humberto Lanz-Mendoza; Ken Teter; Fernando Navarro-García
Journal: Infect Immun Date: 2012-04-30 Impact factor: 3.441

5. Insights into transcriptional silencing and anti-silencing in Shigella flexneri: a detailed molecular analysis of the icsP virulence locus.

Authors: Natasha Weatherspoon-Griffin; Michael A Picker; Krystle L Pew; Hiromichi S Park; Daren R Ginete; Monika Ma Karney; Pashtana Usufzy; Maria I Castellanos; Juan Carlos Duhart; Dustin J Harrison; Jillian N Socea; Alexander D Karabachev; Christopher T Hensley; Amber J Howerton; Rosa Ojeda-Daulo; Joy A Immak; Helen J Wing
Journal: Mol Microbiol Date: 2018-03-23 Impact factor: 3.501