| Literature DB >> 15664865 |
Burkhardt Voigt1, Laurent Meijer, Olivier Lozach, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth.
Abstract
A series of 1-aza-9-oxafluorenes with functionally varied 3-substituents have been prepared from N-phenoxycarbonyl-4-phenyl-1,4-dihydropyridines and p-benzoquinone and biologically evaluated as inhibitors of various cyclin-dependant kinases. The absence of a 3-hydrogen bond acceptor function leads to a complete loss of inhibitory activity. Differing hydrogen bond acceptor functions surprisingly cause significant shifts in the selectivity of inhibition profiles.Entities:
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Year: 2005 PMID： 15664865 DOI： 10.1016/j.bmcl.2004.10.091
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823