| Literature DB >> 15664863 |
Ji Ma1, Shannon H Jones, Rebekah Marshall, Xihan Wu, Sidney M Hecht.
Abstract
An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.Entities:
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Year: 2005 PMID： 15664863 DOI： 10.1016/j.bmcl.2004.10.095
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823