Literature DB >> 15664860

Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides.

Kentaro Hashimoto1, Miyuki Tatsuta, Mikayo Kataoka, Kayo Yasoshima, Yuka Shogase, Makoto Shimazaki, Takeshi Yura, Yingfu Li, Noriyuki Yamamoto, Jang B Gupta, Klaus Urbahns.   

Abstract

A new class of benzimidazole-5-sulfonamides has been identified as nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Initial structure-activity relationships are presented resulting in compounds 19 and 28 with submicromolar dual functional activity on human and rat receptors.

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Year:  2005        PMID： 15664860     DOI： 10.1016/j.bmcl.2004.10.089

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Recent Development of Non-Peptide GnRH Antagonists.

Authors:  Feng-Ling Tukun; Dag Erlend Olberg; Patrick J Riss; Ira Haraldsen; Anita Kaass; Jo Klaveness
Journal:  Molecules       Date:  2017-12-09       Impact factor: 4.411

Review 2.  13C-NMR Chemical Shifts in 1,3-Benzazoles as a Tautomeric Ratio Criterion.

Authors:  Efrén V García-Báez; Itzia I Padilla-Martínez; Alejandro Cruz; Martha C Rosales-Hernández
Journal:  Molecules       Date:  2022-09-23       Impact factor: 4.927
  2 in total

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