| Literature DB >> 15664858 |
Douglas G Batt1, Gregory C Houghton, John Roderick, Joseph B Santella, Dean A Wacker, Patricia K Welch, Yevgeniya I Orlovsky, Eric A Wadman, James M Trzaskos, Paul Davies, Carl P Decicco, Percy H Carter.
Abstract
The synthesis and structure-activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15664858 DOI： 10.1016/j.bmcl.2004.11.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823