D Todder1, Y Bersudsky, H Cohen. 1. Ministry of Health Mental Health Center, Faculty of Health Sciences, Psychiatry Research Unit, Ben Gurion University of the Negev, P.O. Box 4600, Beer-Sheva, Israel. dtoder@netvision.net.il
Abstract
BACKGROUND: The bipolar affective disorder is long been speculated to have an autonomic involvement. Nonlinear analysis of heart rate variability has recently been shown to be a reliable noninvasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. METHODS: We studied 32 euthymic bipolar patients and 24 controls. A high-resolution electrocardiogram was obtained during complete rest. Nonlinear analysis (Poincare plot, largest Lyaponuv exponent, minimal embedding dimension, symbolic dynamic) was used. RESULTS: There wasn't a statistically significant difference in the nonlinear analysis of the heart rate variability, between the euthymic bipolar patients and controls, in the rest situation. CONCLUSION: The nonlinear analysis of heart rate variability didn't support the notation that there is a disturbance in the autonomic nerves system of bipolar patients in the euthymic state.
BACKGROUND: The bipolar affective disorder is long been speculated to have an autonomic involvement. Nonlinear analysis of heart rate variability has recently been shown to be a reliable noninvasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. METHODS: We studied 32 euthymic bipolarpatients and 24 controls. A high-resolution electrocardiogram was obtained during complete rest. Nonlinear analysis (Poincare plot, largest Lyaponuv exponent, minimal embedding dimension, symbolic dynamic) was used. RESULTS: There wasn't a statistically significant difference in the nonlinear analysis of the heart rate variability, between the euthymic bipolarpatients and controls, in the rest situation. CONCLUSION: The nonlinear analysis of heart rate variability didn't support the notation that there is a disturbance in the autonomic nerves system of bipolarpatients in the euthymic state.