Literature DB >> 15664384

PDGF receptor kinase inhibitors for the treatment of restenosis.

Alexander Levitzki1.   

Abstract

The clogging of arteries by neointima is a hallmark of atherosclerosis and of restenosis following balloon angioplasty. The realization in the 1980s that PDGF and its receptor play a key role in the onset of neointimal formation led us to develop PDGFR kinase inhibitors as antirestenosis agents. In this review, we describe the development of these inhibitors and their implementation as antirestenosis agents by localized delivery to the site of injury.

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Year:  2005        PMID： 15664384     DOI： 10.1016/j.cardiores.2004.08.008

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


  29 in total

1.  Lysyl oxidase polymorphisms and ischemic stroke--a case control study.

Authors:  Hai-Feng Zhang; Kai-Jun Zhao; Yi Xu; Bo Hong; Wen-Yuan Zhao; Jian-Min Liu; Qing-Hai Huang
Journal:  Mol Biol Rep       Date:  2012-06-22       Impact factor: 2.316

2.  Can eccentric arterial plaques alone cause flow stagnation points and favour thrombus incorporation?

Authors:  Cristina T Beneli; Priscila F Barbosa; Elaine M Floriano; Mônica A Abreu; Fernando S Ramalho; Jorge Elias Júnior; Marcos A Rossi; Simone G Ramos
Journal:  Int J Exp Pathol       Date:  2009-06       Impact factor: 1.925

3.  An in silico study on the role of smooth muscle cell migration in neointimal formation after coronary stenting.

Authors:  Hannan Tahir; Ioana Niculescu; Carles Bona-Casas; Roeland M H Merks; Alfons G Hoekstra
Journal:  J R Soc Interface       Date:  2015-07-06       Impact factor: 4.118

4.  Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo.

Authors:  Evren Caglayan; Marius Vantler; Olli Leppänen; Felix Gerhardt; Lenard Mustafov; Henrik Ten Freyhaus; Kai Kappert; Margarete Odenthal; Wolfram H Zimmermann; Michelle D Tallquist; Stephan Rosenkranz
Journal:  J Am Coll Cardiol       Date:  2011-06-21       Impact factor: 24.094

5.  Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions.

Authors:  Carolin F Manthey; Christine B Calabio; Anna Wosinski; Elaine M Hanson; Bruce A Vallance; Alex Groisman; Martín G Martín; Jean Y J Wang; Lars Eckmann
Journal:  Am J Physiol Cell Physiol       Date:  2014-05-21       Impact factor: 4.249

6.  Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system.

Authors:  Mark R Battig; Ilia Fishbein; Robert J Levy; Ivan S Alferiev; David Guerrero; Michael Chorny
Journal:  Drug Deliv Transl Res       Date:  2018-08       Impact factor: 4.617

7.  Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.

Authors:  Evgeny A Zemskov; Irina Mikhailenko; Elizabeth P Smith; Alexey M Belkin
Journal:  J Cell Physiol       Date:  2012-05       Impact factor: 6.384

8.  Chronic insulin treatment amplifies PDGF-induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B.

Authors:  Daming Zhuang; Qinghua Pu; Bogdan Ceacareanu; Yingzi Chang; Madhulika Dixit; Aviv Hassid
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-05-02       Impact factor: 4.733

9.  Endothelial injury induces vascular smooth muscle cell proliferation in highly localized regions of a direct contact co-culture system.

Authors:  Jeffrey G Jacot; Joyce Y Wong
Journal:  Cell Biochem Biophys       Date:  2008-09-03       Impact factor: 2.194

Review 10.  Emerging roles for native Orai Ca2+ channels in cardiovascular disease.

Authors:  Brian Ruhle; Mohamed Trebak
Journal:  Curr Top Membr       Date:  2013       Impact factor: 3.049
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