Literature DB >> 1566327

DNA polymerase epsilon: in search of a function.

U Hübscher1, P Thömmes.   

Abstract

The current model of eukaryotic DNA replication involves the two DNA polymerases delta and alpha as the leading and lagging strand enzymes, respectively. A DNA polymerase first discovered in yeast has now been found in all eukaryotic cells and is termed DNA polymerase epsilon. In yeast, the gene for DNA polymerase epsilon has recently been found to be essential for viability, raising new questions about its functions.

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Year:  1992        PMID： 1566327     DOI： 10.1016/0968-0004(92)90499-y

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  13 in total

Review 1.  The sliding clamp of DNA polymerase III holoenzyme encircles DNA.

Authors:  M O'Donnell; J Kuriyan; X P Kong; P T Stukenberg; R Onrust
Journal:  Mol Biol Cell       Date:  1992-09       Impact factor: 4.138

2.  DNA polymerases alpha, delta, and epsilon of Novikoff hepatoma cells differ from those of normal rat liver in physicochemical and catalytic properties.

Authors:  O Popanda; G Fox; H W Thielmann
Journal:  J Mol Med (Berl)       Date:  1995-05       Impact factor: 4.599

3.  Changes of enzymes and factors involved in DNA synthesis during wheat embryo germination.

Authors:  J P Benedetto; R Ech-Chaoui; J Plissonneau; P Laquel; S Litvak; M Castroviejo
Journal:  Plant Mol Biol       Date:  1996-09       Impact factor: 4.076

4.  Preferential inhibition of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells by inhibitors of cell proliferation.

Authors:  G Fox; O Popanda; L Edler; H W Thielmann
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

5.  Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.

Authors:  J Horlacher; M Hottiger; V N Podust; U Hübscher; S A Benner
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

6.  Calf thymus RF-C as an essential component for DNA polymerase delta and epsilon holoenzymes function.

Authors:  V N Podust; A Georgaki; B Strack; U Hübscher
Journal:  Nucleic Acids Res       Date:  1992-08-25       Impact factor: 16.971

7.  The 3'-->5' exonuclease associated with HeLa DNA polymerase epsilon.

Authors:  L Uitto; J Halleen; P Remes; T Kesti; J E Syväoja
Journal:  Chromosoma       Date:  1992       Impact factor: 4.316

8.  Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells.

Authors:  T Basic-Zaninovic; F Palombo; M Bignami; E Dogliotti
Journal:  Nucleic Acids Res       Date:  1992-12-25       Impact factor: 16.971

9.  Lagging strand DNA synthesis by calf thymus DNA polymerases alpha, beta, delta and epsilon in the presence of auxiliary proteins.

Authors:  V N Podust; U Hübscher
Journal:  Nucleic Acids Res       Date:  1993-02-25       Impact factor: 16.971

10.  DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae.

Authors:  Z Wang; X Wu; E C Friedberg
Journal:  Mol Cell Biol       Date:  1993-02       Impact factor: 4.272
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