Literature DB >> 15662960

Synthesis and cytotoxic activity of thiazolofluorenone derivatives.

Hadjila Chabane1, Alain Pierre, Stephane Leonce, Bruno Pfeiffer, Pierre Renard, Valerie Thiery, Gerald Guillaumet, Thierry Besson.   

Abstract

The synthesis and biological evaluation of some novel thiazolofluorenones, thiazolofluorenes and thiazoloanthraquinones, substituted with amino side-chains are described. These polyheterocyclic compounds have been synthesized via the corresponding imino-1,2,3-dithiazoles. Their cytotoxic activity and their eventual selective effect on a phase of the cell cycle were evaluated in vitro, using the murine lymphocytic L1210 leukaemia cell line.

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Year:  2004        PMID： 15662960     DOI： 10.1080/14756360400004607

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  2 in total

1.  Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.

Authors:  Florence Couly; Marine Harari; Carole Dubouilh-Benard; Laetitia Bailly; Emilie Petit; Julien Diharce; Pascal Bonnet; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2018-08-29       Impact factor: 4.411

2.  Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Authors:  Damien Hédou; Carole Dubouilh-Benard; Nadège Loaëc; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2016-06-18       Impact factor: 4.411
  2 in total

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