Literature DB >> 15662950

Microwave-assisted synthesis of novel thiazolocarbazoles and evaluation as potential anticancer agents. Part III.

Alexandra Testard1, Laurent Picot, Ingrid Fruitier-Arnaudin, Jean-Marie Piot, Hadjila Chabane, Lisianne Domon, Valerie Thiery, Thierry Besson.   

Abstract

Novel 6-substituted thiazolocarbazole derivatives have been synthesized under microwave irradiation via the corresponding imino-1,2,3-dithiazoles. In vitro antitumor potential of these polyheterocyclic compounds was evaluated. Among all the tested thiazolocarbazoles, compound 10 is the most effective in inhibiting cell growth.

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Year:  2004        PMID： 15662950     DOI： 10.1080/14756360412331280491

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  2 in total

1.  Development of Kinase Inhibitors via Metal-Catalyzed C⁻H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies.

Authors:  Florence Couly; Marine Harari; Carole Dubouilh-Benard; Laetitia Bailly; Emilie Petit; Julien Diharce; Pascal Bonnet; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2018-08-29       Impact factor: 4.411

2.  Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Authors:  Damien Hédou; Carole Dubouilh-Benard; Nadège Loaëc; Laurent Meijer; Corinne Fruit; Thierry Besson
Journal:  Molecules       Date:  2016-06-18       Impact factor: 4.411
  2 in total

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