AIMS/HYPOTHESIS: Non-HDL cholesterol (the sum of LDL, VLDL and IDL cholesterol) is considered to be particularly valuable in the management of dyslipidaemia in type 2 diabetes. However, it remains uncertain whether the association between non-HDL cholesterol and cardiovascular risk in type 2 diabetes depends on the status of hyperglycaemia. We aimed to determine whether non-HDL cholesterol predicts CHD events among diabetic women independently of currently established risk factors and the status of glycaemic control. METHODS: We prospectively followed 921 diabetic women in the Nurses' Health Study, who were free of cardiovascular disease at the time that blood was drawn in 1989/90. During 10 years of follow-up, we identified 122 incident CHD cases. RESULTS: After adjustment for age, BMI, smoking, alcohol consumption, and other lifestyle risk factors, the multivariate relative risks (RRs) of CHD for extreme quartiles were 1.97 (95% CI: 1.14-3.43) for non-HDL cholesterol, 1.78 (1.02-3.11) for apolipoprotein B-100, and 1.93 (1.15-3.22) for LDL cholesterol. However, the association between non-HDL cholesterol and CHD risk was only apparent among women with elevated fasting triglycerides (RR for extreme quartiles: 3.80; p=0.045). HbA(1)c was strongly associated with increased CHD risk (RR for increase by 1 unit: 1.24; 95% CI: 1.13-1.35), and both non-HDL cholesterol and HbA(1)c additively predicted CHD risk (RR for the combination of high non-HDL cholesterol and high HbA(1)c [tertiles]: 4.59). CONCLUSIONS/ INTERPRETATION: Our study suggests that non-HDL cholesterol and HbA(1)c are potent predictors of CHD risk in diabetic women. Therapies to lower CHD risk in diabetic patients should emphasise both glycaemic control and lipid lowering.
AIMS/HYPOTHESIS: Non-HDL cholesterol (the sum of LDL, VLDL and IDL cholesterol) is considered to be particularly valuable in the management of dyslipidaemia in type 2 diabetes. However, it remains uncertain whether the association between non-HDL cholesterol and cardiovascular risk in type 2 diabetes depends on the status of hyperglycaemia. We aimed to determine whether non-HDL cholesterol predicts CHD events among diabeticwomen independently of currently established risk factors and the status of glycaemic control. METHODS: We prospectively followed 921 diabeticwomen in the Nurses' Health Study, who were free of cardiovascular disease at the time that blood was drawn in 1989/90. During 10 years of follow-up, we identified 122 incident CHD cases. RESULTS: After adjustment for age, BMI, smoking, alcohol consumption, and other lifestyle risk factors, the multivariate relative risks (RRs) of CHD for extreme quartiles were 1.97 (95% CI: 1.14-3.43) for non-HDL cholesterol, 1.78 (1.02-3.11) for apolipoprotein B-100, and 1.93 (1.15-3.22) for LDL cholesterol. However, the association between non-HDL cholesterol and CHD risk was only apparent among women with elevated fasting triglycerides (RR for extreme quartiles: 3.80; p=0.045). HbA(1)c was strongly associated with increased CHD risk (RR for increase by 1 unit: 1.24; 95% CI: 1.13-1.35), and both non-HDL cholesterol and HbA(1)c additively predicted CHD risk (RR for the combination of high non-HDL cholesterol and high HbA(1)c [tertiles]: 4.59). CONCLUSIONS/ INTERPRETATION: Our study suggests that non-HDL cholesterol and HbA(1)c are potent predictors of CHD risk in diabeticwomen. Therapies to lower CHD risk in diabeticpatients should emphasise both glycaemic control and lipid lowering.
Authors: P H Frost; B R Davis; A J Burlando; J D Curb; G P Guthrie; J L Isaacsohn; S Wassertheil-Smoller; A C Wilson; J Stamler Journal: Circulation Date: 1996-11-15 Impact factor: 29.690
Authors: W Willett; M J Stampfer; C Bain; R Lipnick; F E Speizer; B Rosner; D Cramer; C H Hennekens Journal: Am J Epidemiol Date: 1983-06 Impact factor: 4.897
Authors: Weiquan Lu; Helaine E Resnick; Kathleen A Jablonski; Kristina L Jones; Arvind K Jain; Wm James Howard; David C Robbins; Barbara V Howard Journal: Diabetes Care Date: 2003-01 Impact factor: 19.112
Authors: John W Newcomer; Jonathan M Meyer; Ross A Baker; James M Eudicone; Andrei Pikalov; Estelle Vester-Blokland; Robert D McQuade; David T Crandall; William H Carson; Ronald N Marcus; Gilbert L'italien Journal: Schizophr Res Date: 2008-10-29 Impact factor: 4.939
Authors: G Bruno; F Merletti; A Biggeri; G Bargero; S Prina-Cerai; G Pagano; P Cavallo-Perin Journal: Diabetologia Date: 2006-03-09 Impact factor: 10.122
Authors: Nga L Tran; Leila M Barraj; Jacqueline M Heilman; Carolyn G Scrafford Journal: Diabetes Metab Syndr Obes Date: 2014-03-24 Impact factor: 3.168