Conformation changes in albumin molecule as a marker of dissemination of the tumor process.

In 20 patients with stomach cancer the total and effective concentrations of blood albumin were measured using a fluorescent probe and albumin binding reserve was calculated. These parameters in two groups of patients (with local and disseminated process) differed significantly. Evaluation of the effective concentration and albumin binding reserve in cancer patients gives additional valuable information about patient's status. The effective concentration of albumin below 30 g/liter and albumin binding reserve below 70% can be regarded as a prognostically unfavorable sign indicating more extensive dissemination of the tumor process.