Literature DB >> 15662449

Induction of apoptosis in bone marrow cells is mediated via purinergic receptors.

Yu A Uspenskaya1, S V Mikhutkina, E I Taksanova, N N Popova, R Ya Olovyannikova, A B Salmina.   

Abstract

ATP activity in mouse bone marrow cells was in vitro estimated by expression of phosphatidylserine on the outer membrane surface using FITC-labeled annexin. ATP induced apoptosis in bone marrow cells. Purinergic receptor antagonists PPADS and suramin modulated the apoptotic effect of ATP on hemopoietic cells. Acute and subacute administration of doxorubicin, an inductor of oxidative burst, decreased cell sensitivity to ATP and abolished its apoptotic effect.

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Year:  2004        PMID： 15662449     DOI： 10.1023/b:bebm.0000048365.80201.fc

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Uptake of anthracyclines in vitro and in vivo in acute myeloid leukemia cells in relation to apoptosis and clinical response.

Authors:  Alex Bogason; Hasanuzzaman Bhuiyan; Michèle Masquelier; Christer Paul; Astrid Gruber; Sigurd Vitols
Journal:  Eur J Clin Pharmacol       Date:  2009-10-10       Impact factor: 2.953

2.  Ethanolic Extract of Herb Pugun Tanoh (Picria fel-terrae Lour.) Modulates TCD4+ and TCD8+ Cell Profile of Doxorubicin-Induced Immuno-Suppressed Rats.

Authors:  Mustafa Ridwan Lubis; Reny Haryani; Safriana Safriana; Denny Satria
Journal:  Open Access Maced J Med Sci       Date:  2019-11-14

3.  Quercetin Alleviates the Immunotoxic Impact Mediated by Oxidative Stress and Inflammation Induced by Doxorubicin Exposure in Rats.

Authors:  Mayada R Farag; Attia A A Moselhy; Amany El-Mleeh; Samira H Aljuaydi; Tamer Ahmed Ismail; Alessandro Di Cerbo; Giuseppe Crescenzo; Shimaa M Abou-Zeid
Journal:  Antioxidants (Basel)       Date:  2021-11-28
  3 in total

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