| Literature DB >> 15662016 |
Eun Sook Hwang1, Susanne J Szabo, Pamela L Schwartzberg, Laurie H Glimcher.
Abstract
Cell lineage specification depends on both gene activation and gene silencing, and in the differentiation of T helper progenitors to Th1 or Th2 effector cells, this requires the action of two opposing transcription factors, T-bet and GATA-3. T-bet is essential for the development of Th1 cells, and GATA-3 performs an equivalent role in Th2 development. We report that T-bet represses Th2 lineage commitment through tyrosine kinase-mediated interaction between the two transcription factors that interferes with the binding of GATA-3 to its target DNA. These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell.Entities:
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Year: 2005 PMID： 15662016 DOI： 10.1126/science.1103336
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728