Literature DB >> 15661654

The role of SMC proteins in the responses to DNA damage.

Alan R Lehmann1.   

Abstract

The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination.

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Year:  2005        PMID： 15661654     DOI： 10.1016/j.dnarep.2004.07.009

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  37 in total

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