Literature DB >> 15661625

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

Keith A Wafford1.   

Abstract

Chronic use of benzodiazepines for the treatment of anxiety has revealed that these drugs can lead to dependence as indicated by withdrawal symptoms following cessation and tolerance to the drugs effects. Together with their reinforcing properties, this has led to them being labelled as scheduled drugs. Our new knowledge regarding the molecular structure of the benzodiazepine binding site and the growing ability to differentiate GABA(A) receptor subtypes, either by genetic manipulation or subtype selective compounds, have begun to facilitate our understanding of what underlies the mechanism of benzodiazepine dependence. In addition, the involvement of GABA(A) receptors in this phenomenon is leading to a greater understanding of other drugs such as alcohol and opiates.

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Year:  2005        PMID： 15661625     DOI： 10.1016/j.coph.2004.08.006

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  39 in total

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2.  Chronic benzodiazepine-induced reduction in GABA(A) receptor-mediated synaptic currents in hippocampal CA1 pyramidal neurons prevented by prior nimodipine injection.

Authors:  K Xiang; E I Tietz
Journal:  Neuroscience       Date:  2008-08-27       Impact factor: 3.590

Review 3.  GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.

Authors:  Tija C Jacob; Stephen J Moss; Rachel Jurd
Journal:  Nat Rev Neurosci       Date:  2008-05       Impact factor: 34.870

4.  Flurazepam effect on GABAergic currents depends on extracellular pH.

Authors:  T Wójtowicz; P Wyrembek; K Lebida; M Piast; J W Mozrzymas
Journal:  Br J Pharmacol       Date:  2008-03-24       Impact factor: 8.739

5.  Investigating the putative binding-mode of GABA and diazepam within GABA A receptor using molecular modeling.

Authors:  Suqin Ci; Tianrui Ren; Zhiguo Su
Journal:  Protein J       Date:  2008-02       Impact factor: 2.371

6.  Calcium/calmodulin-dependent protein kinase II mediates hippocampal glutamatergic plasticity during benzodiazepine withdrawal.

Authors:  Guofu Shen; Bradley J Van Sickle; Elizabeth I Tietz
Journal:  Neuropsychopharmacology       Date:  2010-05-05       Impact factor: 7.853

Review 7.  Molecular targets for antiepileptic drug development.

Authors:  Brian S Meldrum; Michael A Rogawski
Journal:  Neurotherapeutics       Date:  2007-01       Impact factor: 7.620

Review 8.  Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond.

Authors:  Stephanie C Licata; James K Rowlett
Journal:  Pharmacol Biochem Behav       Date:  2008-01-12       Impact factor: 3.533

9.  Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal.

Authors:  Paromita Das; Scott M Lilly; Ricardo Zerda; William T Gunning; Francisco J Alvarez; Elizabeth I Tietz
Journal:  J Comp Neurol       Date:  2008-12-20       Impact factor: 3.215

10.  alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation.

Authors:  Mariana Vargas-Caballero; Loren J Martin; Michael W Salter; Beverley A Orser; Ole Paulsen
Journal:  Neuropharmacology       Date:  2009-11-23       Impact factor: 5.250
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