Literature DB >> 15661524

Kinesin: world's tiniest biped.

Charles L Asbury1.   

Abstract

Kinesin, an essential motor protein that moves intracellular cargo along microtubules, walks like a person. When we walk, our feet exchange roles with each step, one moving and one remaining stationary. The moving foot travels twice as far as our torso during a single step, and our body alternates between two configurations (left vs. right leg leading). Recent work shows that kinesin shares all three of these hallmarks of bipedal walking. The challenge now is to determine how the gait of this lilliputian biped is coordinated.

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Year:  2005        PMID: 15661524     DOI: 10.1016/j.ceb.2004.12.002

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN: 0955-0674            Impact factor:   8.382


  20 in total

1.  Kinesin motor activation: microtubules pull the switches.

Authors:  Franck Fourniol; Carolyn A Moores
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-17       Impact factor: 11.205

Review 2.  To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.

Authors:  Megan T Valentine; Susan P Gilbert
Journal:  Curr Opin Cell Biol       Date:  2006-12-26       Impact factor: 8.382

3.  On the hand-over-hand mechanism of kinesin.

Authors:  Qiang Shao; Yi Qin Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-12       Impact factor: 11.205

4.  Two distinct modes of processive kinesin movement in mixtures of ATP and AMP-PNP.

Authors:  Radhika Subramanian; Jeff Gelles
Journal:  J Gen Physiol       Date:  2007-11       Impact factor: 4.086

5.  The Tumbleweed: towards a synthetic proteinmotor.

Authors:  Elizabeth H C Bromley; Nathan J Kuwada; Martin J Zuckermann; Roberta Donadini; Laleh Samii; Gerhard A Blab; Gregory J Gemmen; Benjamin J Lopez; Paul M G Curmi; Nancy R Forde; Derek N Woolfson; Heiner Linke
Journal:  HFSP J       Date:  2009-04-28

6.  Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics.

Authors:  Amy Unsworth; Hirohisa Masuda; Susheela Dhut; Takashi Toda
Journal:  Mol Biol Cell       Date:  2008-09-17       Impact factor: 4.138

7.  On the origin of kinesin limping.

Authors:  Adrian N Fehr; Braulio Gutiérrez-Medina; Charles L Asbury; Steven M Block
Journal:  Biophys J       Date:  2009-09-16       Impact factor: 4.033

8.  Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping.

Authors:  Braulio Gutiérrez-Medina; Adrian N Fehr; Steven M Block
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-23       Impact factor: 11.205

Review 9.  Catch and release: how do kinetochores hook the right microtubules during mitosis?

Authors:  Krishna K Sarangapani; Charles L Asbury
Journal:  Trends Genet       Date:  2014-03-13       Impact factor: 11.639

Review 10.  Mechanism of processive movement of monomeric and dimeric kinesin molecules.

Authors:  Ping Xie
Journal:  Int J Biol Sci       Date:  2010-11-03       Impact factor: 6.580

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