Literature DB >> 15661386

A novel intranasal Protollin-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice.

Sophie Chabot1, Angela Brewer, George Lowell, Martin Plante, Sonya Cyr, David S Burt, Brian J Ward.   

Abstract

Protollin-MV is a vaccine produced by mixing split measles virus (MV) antigen with the novel adjuvant Protollin (Neisseria meningitidis outer membrane proteins non-covalently complexed with Shigella flexneri 2a lipopolysaccharide). Intranasal immunization of mice with two or three doses of Protollin-MV induces both serum IgG and mucosal IgA with strong neutralizing activity. There is a dose-dependent shift towards lower IgG1:IgG2a ratios and MV-specific IFNgamma production in splenocytes. Intranasal Protollin-MV can therefore induce systemic and mucosal neutralizing antibody responses as well as elicit a balanced TH1/TH2-type response.

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Year:  2005        PMID： 15661386     DOI： 10.1016/j.vaccine.2004.09.010

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  13 in total

Review 1.  Mucosal vaccines: recent progress in understanding the natural barriers.

Authors:  Olga Borges; Filipa Lebre; Dulce Bento; Gerrit Borchard; Hans E Junginger
Journal:  Pharm Res       Date:  2009-12-01       Impact factor: 4.200

Review 2.  Innate immune function of the neisserial porins and the relationship to vaccine adjuvant activity.

Authors:  Lee M Wetzler
Journal:  Future Microbiol       Date:  2010-05       Impact factor: 3.165

3.  Effects of different adjuvants in the context of intramuscular and intranasal routes on humoral and cellular immune responses induced by detergent-split A/H3N2 influenza vaccines in mice.

Authors:  Mariana Baz; Mukesh Samant; Hakima Zekki; Pascale Tribout-Jover; Martin Plante; Anne-Marie Lanteigne; Marie-Eve Hamelin; Corey Mallett; Barbara Papadopoulou; Guy Boivin
Journal:  Clin Vaccine Immunol       Date:  2011-12-21

4.  The EtpA exoprotein of enterotoxigenic Escherichia coli promotes intestinal colonization and is a protective antigen in an experimental model of murine infection.

Authors:  Koushik Roy; David Hamilton; Kenneth P Allen; Mildred P Randolph; James M Fleckenstein
Journal:  Infect Immun       Date:  2008-02-19       Impact factor: 3.441

5.  Comparison of the immune responses induced by chimeric alphavirus-vectored and formalin-inactivated alum-precipitated measles vaccines in mice.

Authors:  M Jeff Bergen; Chien-Hsiung Pan; Catherine E Greer; Harold S Legg; John M Polo; Diane E Griffin
Journal:  PLoS One       Date:  2010-04-22       Impact factor: 3.240

Review 6.  Intestinal M cells: the fallible sentinels?

Authors:  Harvey Miller; Jianbing Zhang; Rhonda Kuolee; Girishchandra B Patel; Wangxue Chen
Journal:  World J Gastroenterol       Date:  2007-03-14       Impact factor: 5.742

7.  Directed evaluation of enterotoxigenic Escherichia coli autotransporter proteins as putative vaccine candidates.

Authors:  Jessica A Harris; Koushik Roy; Virginia Woo-Rasberry; David J Hamilton; Rita Kansal; Firdausi Qadri; James M Fleckenstein
Journal:  PLoS Negl Trop Dis       Date:  2011-12-06

8.  Nasal delivery of Protollin-adjuvanted H5N1 vaccine induces enhanced systemic as well as mucosal immunity in mice.

Authors:  Weiping Cao; Jin Hyang Kim; Adrian J Reber; Mary Hoelscher; Jessica A Belser; Xiuhua Lu; Jacqueline M Katz; Shivaprakash Gangappa; Martin Plante; David S Burt; Suryaprakash Sambhara
Journal:  Vaccine       Date:  2017-05-09       Impact factor: 3.641

9.  Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches.

Authors:  N G Anosova; S Chabot; V Shreedhar; J A Borawski; B L Dickinson; M R Neutra
Journal:  Mucosal Immunol       Date:  2008-01       Impact factor: 7.313

10.  Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin.

Authors:  Qingwei Luo; Tim J Vickers; James M Fleckenstein
Journal:  Clin Vaccine Immunol       Date:  2016-07-05
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