| Literature DB >> 15661377 |
Topi Tervonen1, Karl Akerman, Ben A Oostra, Maija Castrén.
Abstract
In the Fmr1 knockout mice, a model for fragile X mental retardation syndrome, the levels of regulator of G-protein signaling (Rgs) 4 but not Rgs2 mRNA were considerably reduced (65% from control) in the cerebral cortex and hippocampal CA1 region. The expression of Rgs4 was normal in animals lacking a related protein, FXR2P, indicating that the decrease in Rgs4 expression was specific for the absence of FMRP, and suggests a role for FMRP in G-protein signaling.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15661377 DOI： 10.1016/j.molbrainres.2004.09.023
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X