| Literature DB >> 15661263 |
Cemaliye Boylu Akyerli1, Meral Beksac, Michelle Holko, Mathias Frevel, Klara Dalva, Uğur Ozbek, Ender Soydan, Muhit Ozcan, Gülsüm Ozet, Osman Ilhan, Günhan Gürman, Hamdi Akan, Bryan R G Williams, Tayfun Ozçelik.
Abstract
We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.Entities:
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Year: 2005 PMID： 15661263 DOI： 10.1016/j.leukres.2004.07.007
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156