| Literature DB >> 15661025 |
Silvia Giliani1, Luigi Mori, Geneviève de Saint Basile, Francoise Le Deist, Carmen Rodriguez-Perez, Concetta Forino, Evelina Mazzolari, Sophie Dupuis, Ronit Elhasid, Aharon Kessel, Claire Galambrun, Juana Gil, Alain Fischer, Amos Etzioni, Luigi D Notarangelo.
Abstract
Analysis of gene-targeted mice and patients with severe combined immunodeficiency due to mutations of the alpha chain of the interleukin-7 receptor (IL-7Ralpha) has shown important differences between mice and humans in the role played by IL-7 in lymphoid development. More recently, it has been shown that IL-7Ralpha is also shared by the receptor for another cytokine, thymic stromal lymphopoietin (TSLP). In this review, we discuss recent advances in IL-7- and TSLP-mediated signaling. We also report on the clinical and immunological features of 16 novel patients with IL-7Ralpha deficiency and discuss the results of hematopoietic stem cell transplantation.Entities:
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Year: 2005 PMID： 15661025 DOI： 10.1111/j.0105-2896.2005.00234.x
Source DB: PubMed Journal: Immunol Rev ISSN： 0105-2896 Impact factor: 12.988