Literature DB >> 1566086

Reciprocal regulation of adipogenesis by Myc and C/EBP alpha.

S O Freytag1, T J Geddes.   

Abstract

3T3-L1 adipoblasts that express large amounts of c-Myc cannot terminally differentiate, raising the possibility that Myc inhibits the expression of genes that promote adipogenesis. The CCAAT/enhancer binding protein (C/EBP alpha) is induced during 3T3-L1 adipogenesis when cells commit to the differentiation pathway. Transfection of 3T3-L1 adipoblasts with the gene that encodes C/EBP alpha caused overt expression of the adipocyte morphology. Expression of Myc prohibited the normal induction of C/EBP alpha and prevented adipogenesis. Enforced expression of C/EBP alpha overcame the Myc-induced block to differentiation. These results provide a molecular basis for the regulation of adipogenesis and implicate Myc and C/EBP alpha as pivotal controlling elements.

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Year:  1992        PMID： 1566086     DOI： 10.1126/science.256.5055.379

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  86 in total

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8.  Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.

Authors:  W C Yeh; B E Bierer; S L McKnight
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9.  CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

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Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971
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