Literature DB >> 15660734

Healing diabetic neuropathic foot ulcers: are we getting better?

D J Margolis1, L Allen-Taylor, O Hoffstad, J A Berlin.   

Abstract

AIM: To benchmark by year the likelihood that an individual with a diabetic neuropathic foot ulcer will heal over more than a 10-year period. PATIENTS AND METHODS: A cohort study within a multicentre wound care network of individuals with a diabetic neuropathic foot ulcer who were treated by a standard wound care algorithm. The main outcome was a healed wound by the 20th week of care stratified by calendar year.
RESULTS: We evaluated 27 193 individuals with a neuropathic foot ulcer. Between 1988 and 1990 approximately 66% of patients did not heal. By 1999 this percentage had decreased to 49%. The change in the rate of failure to heal is very closely associated with an increase over time in the proportion of patients seen with wounds identified as prognostically favourable using a previously published prognostic model (i.e. individuals with wounds < or = 2 cm2, wounds < or = 2 months old, and wounds of grade < or = 2). Nevertheless, even among those most likely to heal, the likelihood of failing to heal went from 62% prior to 1991 to 32% in 2000.
CONCLUSIONS: We have shown that individuals with a diabetic neuropathic foot ulcer seeking care are more likely to heal today than 10 years ago. The primary reason for this improvement is that individuals are seeking care when their wounds are most easily treated and these are now more likely to heal.

Entities:  

Mesh:

Year:  2005        PMID: 15660734     DOI: 10.1111/j.1464-5491.2004.01375.x

Source DB:  PubMed          Journal:  Diabet Med        ISSN: 0742-3071            Impact factor:   4.359


  15 in total

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Review 2.  Benefit-risk assessment of becaplermin in the treatment of diabetic foot ulcers.

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Journal:  Drug Saf       Date:  2010-06-01       Impact factor: 5.606

Review 3.  Prolotherapy: Potential for the Treatment of Chronic Wounds?

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Journal:  Adv Wound Care (New Rochelle)       Date:  2019-04-03       Impact factor: 4.730

4.  Effective management of patients with diabetes foot ulcers: outcomes of an Interprofessional Diabetes Foot Ulcer Team.

Authors:  Rajna Ogrin; Pamela E Houghton; G William Thompson
Journal:  Int Wound J       Date:  2013-07-09       Impact factor: 3.315

5.  Evaluation of the use of prognostic information for the care of individuals with venous leg ulcers or diabetic neuropathic foot ulcers.

Authors:  Shanu K Kurd; Ole J Hoffstad; Warren B Bilker; David J Margolis
Journal:  Wound Repair Regen       Date:  2009 May-Jun       Impact factor: 3.617

Review 6.  Chronic wounds.

Authors:  Vincent Falanga; Roslyn Rivkah Isseroff; Athena M Soulika; Marco Romanelli; David Margolis; Suzanne Kapp; Mark Granick; Keith Harding
Journal:  Nat Rev Dis Primers       Date:  2022-07-21       Impact factor: 65.038

7.  Allogeneic keratinocyte for intractable chronic diabetic foot ulcers: A prospective observational study.

Authors:  Yeok G Hwang; Jin W Lee; Kwang H Park; Seung H Han
Journal:  Int Wound J       Date:  2019-01-02       Impact factor: 3.315

8.  Diabetic foot ulcer management in clinical practice in the UK: costs and outcomes.

Authors:  Julian F Guest; Graham W Fuller; Peter Vowden
Journal:  Int Wound J       Date:  2017-12-15       Impact factor: 3.315

Review 9.  Optimizing Wound Bed Preparation With Collagenase Enzymatic Debridement.

Authors:  Stanley K McCallon; Dorothy Weir; John C Lantis
Journal:  J Am Coll Clin Wound Spec       Date:  2015-08-15

10.  Lack of effectiveness of hyperbaric oxygen therapy for the treatment of diabetic foot ulcer and the prevention of amputation: a cohort study.

Authors:  David J Margolis; Jayanta Gupta; Ole Hoffstad; Maryte Papdopoulos; Henry A Glick; Stephen R Thom; Nandita Mitra
Journal:  Diabetes Care       Date:  2013-02-19       Impact factor: 19.112

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