OBJECTIVE: To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women. DESIGN: Nested case-control study. SETTING: Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demographiques. PARTICIPANTS: 3505 women with asthma, totalling 4593 pregnancies, between 1990 and 2000. MAIN OUTCOME MEASURES: Pregnancy induced hypertension and pre-eclampsia. RESULTS: 302 cases of pregnancy induced hypertension and 165 cases of pre-eclampsia were identified. Use of inhaled corticosteroids from conception until date of outcome was not associated with an increased risk of pregnancy induced hypertension (adjusted odds ratio 1.02, 95% confidence interval 0.77 to 1.34) or pre-eclampsia (1.06, 0.74 to 1.53). No significant dose-response relation was observed between inhaled corticosteroids and pregnancy induced hypertension or pre-eclampsia. Oral corticosteroids were significantly associated with the risk of pregnancy induced hypertension (adjusted odds ratio 1.57, 1.02 to 2.41), and a trend was seen for pre-eclampsia (1.72, 0.98 to 3.02). CONCLUSION: No significant increase of the risk of pregnancy induced hypertension or pre-eclampsia was detected among users of inhaled corticosteroids during pregnancy, while markers of uncontrolled and severe asthma were found to significantly increase the risks of pregnancy induced hypertension and pre-eclampsia.
OBJECTIVE: To determine whether the use of inhaled corticosteroids during pregnancy increases the risk of pregnancy induced hypertension and pre-eclampsia among asthmatic women. DESIGN: Nested case-control study. SETTING: Three administrative health databases from Quebec: RAMQ, MED-ECHO, and Fichier des evenements demographiques. PARTICIPANTS: 3505 women with asthma, totalling 4593 pregnancies, between 1990 and 2000. MAIN OUTCOME MEASURES: Pregnancy induced hypertension and pre-eclampsia. RESULTS: 302 cases of pregnancy induced hypertension and 165 cases of pre-eclampsia were identified. Use of inhaled corticosteroids from conception until date of outcome was not associated with an increased risk of pregnancy induced hypertension (adjusted odds ratio 1.02, 95% confidence interval 0.77 to 1.34) or pre-eclampsia (1.06, 0.74 to 1.53). No significant dose-response relation was observed between inhaled corticosteroids and pregnancy induced hypertension or pre-eclampsia. Oral corticosteroids were significantly associated with the risk of pregnancy induced hypertension (adjusted odds ratio 1.57, 1.02 to 2.41), and a trend was seen for pre-eclampsia (1.72, 0.98 to 3.02). CONCLUSION: No significant increase of the risk of pregnancy induced hypertension or pre-eclampsia was detected among users of inhaled corticosteroids during pregnancy, while markers of uncontrolled and severe asthma were found to significantly increase the risks of pregnancy induced hypertension and pre-eclampsia.
Authors: Mitchell P Dombrowski; Michael Schatz; Robert Wise; Elizabeth A Thom; Mark Landon; William Mabie; Roger B Newman; Donald McNellis; John C Hauth; Marshall Lindheimer; Steve N Caritis; Kenneth J Leveno; Paul Meis; Menachem Miodovnik; Ronald J Wapner; Michael W Varner; Mary Jo O'Sullivan; Deborah L Conway Journal: Am J Obstet Gynecol Date: 2004-03 Impact factor: 8.661
Authors: Stephanie Brien; Jeffrey C Kwong; Katia M Charland; Aman D Verma; John S Brownstein; David L Buckeridge Journal: Am J Epidemiol Date: 2012-10-16 Impact factor: 4.897