| Literature DB >> 15659060 |
Estella A Koppel1, Klaas P J M van Gisbergen, Teunis B H Geijtenbeek, Yvette van Kooyk.
Abstract
Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.Entities:
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Year: 2005 PMID： 15659060 DOI： 10.1111/j.1462-5822.2004.00480.x
Source DB: PubMed Journal: Cell Microbiol ISSN： 1462-5814 Impact factor: 3.715