| Literature DB >> 15658849 |
Paola Dozzo1, Myoung-Seo Koo, Stephanie Berger, Trudy M Forte, Stephen B Kahl.
Abstract
The efficacy of binary cancer therapies such as BNCT and PDT depends critically on the subcellular localization site of the sensitizer. This work presents the synthesis and plasma lipoprotein binding properties of the first reported binary conjugate of a boronated porphyrin with a peptide nuclear localization sequence. The porphyrin-NLS conjugate associates in vitro predominantly with low density lipoproteins. Such association provides a potentially selective entry pathway into malignant cells that overexpress the LDL receptor.Entities:
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Year: 2005 PMID： 15658849 DOI： 10.1021/jm049277q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446