| Literature DB >> 15656928 |
Abstract
The definition of BE has evolved over time. BE is the key premalignant lesion for developing EAC. The epidemiology and pathophysiology of BE is outlined, and risk factors for BE and EAC are reviewed. GERD plays a crucial role in the pathophysiology and the clinical identification of BE. Endoscopy with biopsy is the best tool for diagnosing and surveying patients with BE. Detection of early neoplasia is the present approach to reduce EAC mortality. Novel technology should assist in the early detection of dysplasia to enable targeted therapy. Effective chemopreventive strategies may reduce the risk of progression to EAC.Entities:
Mesh:
Year: 2005 PMID: 15656928 DOI: 10.1016/j.mcna.2004.08.008
Source DB: PubMed Journal: Med Clin North Am ISSN: 0025-7125 Impact factor: 5.456