Literature DB >> 15655252

Molecular mechanism of scorpion neurotoxins acting on sodium channels: insight into their diverse selectivity.

Xiao-Pan Zuo1, Yong-Hua Ji.   

Abstract

Scorpion toxins that affect sodium channel gating traditionally are divided into alpha- and beta-classes. They show vast diversity in their selectivity for phyletic- or isoform-specific sodium channels. This article discusses the molecular mechanism of the selectivity. Moreover, a phylogenetic tree of scorpion toxins has been constructed, which, together with the worldwide distribution of toxins and the zoogeographic dispersion of the studied genera, offers an insight into the evolution of diverse scorpion toxins.

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Year:  2004        PMID： 15655252     DOI： 10.1385/MN:30:3:265

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  59 in total

1.  A scorpion alpha-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons.

Authors:  N Gilles; C Blanchet; I Shichor; M Zaninetti; I Lotan; D Bertrand; D Gordon
Journal:  J Neurosci       Date:  1999-10-15       Impact factor: 6.167

2.  Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel.

Authors:  X L He; H M Li; Z H Zeng; X Q Liu; M Wang; D C Wang
Journal:  J Mol Biol       Date:  1999-09-10       Impact factor: 5.469

3.  Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaIT.

Authors:  H Chen; D Gordon; S H Heinemann
Journal:  Pflugers Arch       Date:  2000-02       Impact factor: 3.657

4.  Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel.

Authors:  Iris Shichor; Eliahu Zlotkin; Nitza Ilan; Dodo Chikashvili; Walter Stuhmer; Dalia Gordon; Ilana Lotan
Journal:  J Neurosci       Date:  2002-06-01       Impact factor: 6.167

5.  Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects.

Authors:  S Cestèle; M Stankiewicz; P Mansuelle; M De Waard; B Dargent; N Gilles; M Pelhate; H Rochat; M F Martin-Eauclaire; D Gordon
Journal:  Eur J Neurosci       Date:  1999-03       Impact factor: 3.386

6.  Functional duality and structural uniqueness of depressant insect-selective neurotoxins.

Authors:  E Zlotkin; M Eitan; V P Bindokas; M E Adams; M Moyer; W Burkhart; E Fowler
Journal:  Biochemistry       Date:  1991-05-14       Impact factor: 3.162

7.  Effects of Tityus serrulatus scorpion toxin gamma on voltage-gated Na+ channels.

Authors:  P Marcotte; L Q Chen; R G Kallen; M Chahine
Journal:  Circ Res       Date:  1997-03       Impact factor: 17.367

8.  An anti-insect toxin purified from the scorpion Androctonus australis Hector also acts on the alpha- and beta-sites of the mammalian sodium channel: sequence and circular dichroism study.

Authors:  E P Loret; M F Martin-Eauclaire; P Mansuelle; F Sampieri; C Granier; H Rochat
Journal:  Biochemistry       Date:  1991-01-22       Impact factor: 3.162

9.  Biochemical and electrophysiological characteristics of toxins isolated from the venom of the scorpion Centruroides sculpturatus.

Authors:  H Meves; J M Simard; D D Watt
Journal:  J Physiol (Paris)       Date:  1984

10.  Proton nuclear magnetic resonance and distance geometry/simulated annealing studies on the variant-1 neurotoxin from the New World scorpion Centruroides sculpturatus Ewing.

Authors:  W Lee; M J Jablonsky; D D Watt; N R Krishna
Journal:  Biochemistry       Date:  1994-03-08       Impact factor: 3.162
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  13 in total

Review 1.  Voltage-gated sodium channel modulation by scorpion alpha-toxins.

Authors:  Frank Bosmans; Jan Tytgat
Journal:  Toxicon       Date:  2006-09-28       Impact factor: 3.033

2.  Chinese-scorpion (Buthus martensi Karsch) toxin BmK alphaIV, a novel modulator of sodium channels: from genomic organization to functional analysis.

Authors:  Zhi-Fang Chai; Mang-Mang Zhu; Zhan-Tao Bai; Tong Liu; Miao Tan; Xue-Yan Pang; Yong-Hua Ji
Journal:  Biochem J       Date:  2006-11-01       Impact factor: 3.857

3.  Pharmacological kinetics of BmK AS, a sodium channel site 4-specific modulator on Nav1.3.

Authors:  Zhi-Rui Liu; Jie Tao; Bang-Qian Dong; Gang Ding; Zhi-Jun Cheng; Hui-Qiong He; Yong-Hua Ji
Journal:  Neurosci Bull       Date:  2012-06       Impact factor: 5.203

Review 4.  Exploring the obscure profiles of pharmacological binding sites on voltage-gated sodium channels by BmK neurotoxins.

Authors:  Zhi-Rui Liu; Pin Ye; Yong-Hua Ji
Journal:  Protein Cell       Date:  2011-07-12       Impact factor: 14.870

5.  Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy.

Authors:  R Zhao; X-Y Zhang; J Yang; C-C Weng; L-L Jiang; J-W Zhang; X-Q Shu; Y-H Ji
Journal:  Br J Pharmacol       Date:  2008-04-21       Impact factor: 8.739

Review 6.  Scorpion venom components that affect ion-channels function.

Authors:  V Quintero-Hernández; J M Jiménez-Vargas; G B Gurrola; H H Valdivia; L D Possani
Journal:  Toxicon       Date:  2013-07-26       Impact factor: 3.033

7.  Leftward shift in the voltage-dependence for Ca2+ currents activation induced by a new toxin from Phoneutria reidyi (Aranae, Ctenidae) venom.

Authors:  L B Vieira; A M C Pimenta; M Richardson; M P Bemquerer; H J Reis; J S Cruz; M V Gomez; M M Santoro; R Ferreira-de-Oliveira; S G Figueiredo; T P Snutch; M N Cordeiro
Journal:  Cell Mol Neurobiol       Date:  2006-12-07       Impact factor: 4.231

8.  Mining the virgin land of neurotoxicology: a novel paradigm of neurotoxic peptides action on glycosylated voltage-gated sodium channels.

Authors:  Zhirui Liu; Jie Tao; Pin Ye; Yonghua Ji
Journal:  J Toxicol       Date:  2012-07-08

9.  Scorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats.

Authors:  Pin Ye; Yunlu Jiao; Zhenwei Li; Liming Hua; Jin Fu; Feng Jiang; Tong Liu; Yonghua Ji
Journal:  Protein Cell       Date:  2015-04-24       Impact factor: 14.870

10.  Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators.

Authors:  Mandë Holford; Sebastian Auer; Martin Laqua; Ines Ibañez-Tallon
Journal:  Front Mol Neurosci       Date:  2009-10-30       Impact factor: 5.639
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