HYPOTHESIS: Some risk factors associated with breast cancer may be more predictive of estrogen receptor (ER)- positive than ER-negative tumors. DESIGN: Survey of patients enrolled in a study of breast cancer risk factors. SETTING: Community population in a northern California county. PATIENTS: A total of 234 individuals diagnosed as having breast cancer between July 1, 1997, and June 30, 1999, reporting Marin County, California, residence and participating in a questionnaire regarding exposure to breast cancer risk factors. MAIN OUTCOME MEASURE: Diagnosis of ER-positive vs ER-negative breast cancer. RESULTS: Comparison between ER-positive and ER-negative cases showed several factors predictive of ER-positive tumors. In a multivariate model, years of hormone therapy use remained the most significant predictor of ER-positive disease. CONCLUSIONS: Patients diagnosed as having ER-positive breast cancer were more likely to have undergone hormone therapy. The excess of ER-positive breast cancers reported in Marin County could, therefore, in part, be related to hormone therapy.
HYPOTHESIS: Some risk factors associated with breast cancer may be more predictive of estrogen receptor (ER)- positive than ER-negative tumors. DESIGN: Survey of patients enrolled in a study of breast cancer risk factors. SETTING: Community population in a northern California county. PATIENTS: A total of 234 individuals diagnosed as having breast cancer between July 1, 1997, and June 30, 1999, reporting Marin County, California, residence and participating in a questionnaire regarding exposure to breast cancer risk factors. MAIN OUTCOME MEASURE: Diagnosis of ER-positive vs ER-negative breast cancer. RESULTS: Comparison between ER-positive and ER-negative cases showed several factors predictive of ER-positive tumors. In a multivariate model, years of hormone therapy use remained the most significant predictor of ER-positive disease. CONCLUSIONS:Patients diagnosed as having ER-positive breast cancer were more likely to have undergone hormone therapy. The excess of ER-positive breast cancers reported in Marin County could, therefore, in part, be related to hormone therapy.
Authors: Aishwarya Kulkarni; Antoinette M Stroup; Lisa E Paddock; Stephanie M Hill; Jesse J Plascak; Adana A M Llanos Journal: Cancer Health Disparities Date: 2019-08-19
Authors: Halei C Benefield; Emily C Zabor; Yue Shan; Emma H Allott; Colin B Begg; Melissa A Troester Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-08-08 Impact factor: 4.254
Authors: Rochelle R Ereman; Lee Ann Prebil; Mary Mockus; Kathy Koblick; Fern Orenstein; Christopher Benz; Christina A Clarke Journal: BMC Public Health Date: 2010-04-30 Impact factor: 3.295
Authors: Lei Quan; Chi-Chen Hong; Gary Zirpoli; Michelle R Roberts; Thaer Khoury; Lara E Sucheston-Campbell; Dana H Bovbjerg; Lina Jandorf; Karen Pawlish; Gregory Ciupak; Warren Davis; Elisa V Bandera; Christine B Ambrosone; Song Yao Journal: Endocr Relat Cancer Date: 2014-09-16 Impact factor: 5.678