BACKGROUND AND OBJECTIVE: Specific screening tests to detect post-stroke dementia are lacking. We recently reported that an adaptation of the Cambridge Cognitive Examination (CAMCOG), the Rotterdam-CAMCOG, had excellent sensitivity and specificity for detecting post-stroke dementia. In this study, we externally validated the diagnostic accuracy of the R-CAMCOG in a new, representative cohort of stroke patients. METHODS: The R-CAMCOG and an extensive neuropsychological examination were administered, independently of each other, in 121 patients aged 55 and over with a stroke in the preceding three to nine months. The gold standard diagnosis of dementia was based on the results of the extensive neuropsychological examination, clinical presentation, and information from a close relative, as well as DSM-IV criteria. RESULTS: Of the 121 patients, 35 had dementia (29%). The diagnostic accuracy at the pre-specified cut-off point of 33/34 was established through receiver operating characteristic (ROC) analyses (sensitivity 66%, specificity 94%). At a cut-off point of 36/37 sensitivity would be 83% and specificity 78%. CONCLUSION: The R-CAMCOG is a useful screening tool for post-stroke dementia in a clinical setting.
BACKGROUND AND OBJECTIVE: Specific screening tests to detect post-stroke dementia are lacking. We recently reported that an adaptation of the Cambridge Cognitive Examination (CAMCOG), the Rotterdam-CAMCOG, had excellent sensitivity and specificity for detecting post-stroke dementia. In this study, we externally validated the diagnostic accuracy of the R-CAMCOG in a new, representative cohort of strokepatients. METHODS: The R-CAMCOG and an extensive neuropsychological examination were administered, independently of each other, in 121 patients aged 55 and over with a stroke in the preceding three to nine months. The gold standard diagnosis of dementia was based on the results of the extensive neuropsychological examination, clinical presentation, and information from a close relative, as well as DSM-IV criteria. RESULTS: Of the 121 patients, 35 had dementia (29%). The diagnostic accuracy at the pre-specified cut-off point of 33/34 was established through receiver operating characteristic (ROC) analyses (sensitivity 66%, specificity 94%). At a cut-off point of 36/37 sensitivity would be 83% and specificity 78%. CONCLUSION: The R-CAMCOG is a useful screening tool for post-stroke dementia in a clinical setting.
Authors: Renske Uiterwijk; Marjolein Huijts; Julie Staals; Rob P W Rouhl; Peter W De Leeuw; Abraham A Kroon; Robert J Van Oostenbrugge Journal: Am J Hypertens Date: 2015-08-12 Impact factor: 2.689
Authors: Renske Uiterwijk; Julie Staals; Marjolein Huijts; Peter W de Leeuw; Abraham A Kroon; Robert J van Oostenbrugge Journal: J Clin Hypertens (Greenwich) Date: 2018-01-22 Impact factor: 3.738
Authors: Renske Uiterwijk; Robert J van Oostenbrugge; Marjolein Huijts; Peter W De Leeuw; Abraham A Kroon; Julie Staals Journal: Front Aging Neurosci Date: 2016-12-12 Impact factor: 5.750
Authors: Stephen David James Makin; Sarah Turpin; Martin S Dennis; Joanna M Wardlaw Journal: J Neurol Neurosurg Psychiatry Date: 2013-03-01 Impact factor: 10.154
Authors: Renske Uiterwijk; Julie Staals; Marjolein Huijts; Sander M J van Kuijk; Peter W de Leeuw; Abraham A Kroon; Robert J van Oostenbrugge Journal: J Clin Hypertens (Greenwich) Date: 2018-09-11 Impact factor: 3.738