Literature DB >> 15653837

Airway remodeling in asthma: therapeutic implications of mechanisms.

Robert J Homer1, Jack A Elias.   

Abstract

Asthma is currently recognized as a chronic inflammatory disorder of the airways that leads to tissue injury and subsequent structural changes collectively called airway remodeling. Transgenic modeling of inflammatory mediators allows for the discovery of unexpected effects, dissection of downstream signaling events, and clues to future therapies.

Entities:  

Mesh：

Year:  2005        PMID： 15653837     DOI： 10.1152/physiol.00035.2004

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  50 in total

1.  Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis?

Authors:  S I Said; S A Hamidi; L Gonzalez Bosc
Journal:  Eur Respir J       Date:  2010-04       Impact factor: 16.671

2.  Quantification of airway fibrosis in asthma by flow cytometry.

Authors:  Andrew Reichard; Nicholas Wanner; Eric Stuehr; Mario Alemagno; Kelly Weiss; Kimberly Queisser; Serpil Erzurum; Kewal Asosingh
Journal:  Cytometry A       Date:  2018-04-16       Impact factor: 4.355

3.  Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation.

Authors:  Leena P Desai; Steven R White; Christopher M Waters
Journal:  J Biol Chem       Date:  2009-12-14       Impact factor: 5.157

4.  Interleukin-20 promotes airway remodeling in asthma.

Authors:  Wenbin Gong; Xin Wang; Yuguo Zhang; Junqing Hao; Chunyan Xing; Qi Chu; Guicheng Wang; Jiping Zhao; Junfei Wang; Qian Dong; Tian Liu; Yuanyuan Zhang; Liang Dong
Journal:  Inflammation       Date:  2014-12       Impact factor: 4.092

5.  Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.

Authors:  Omar A Jaffer; A Brent Carter; Philip N Sanders; Megan E Dibbern; Christopher J Winters; Shubha Murthy; Alan J Ryan; Adam G Rokita; Anand M Prasad; Joseph Zabner; Joel N Kline; Isabella M Grumbach; Mark E Anderson
Journal:  Am J Respir Cell Mol Biol       Date:  2015-01       Impact factor: 6.914

Review 6.  Putting the Squeeze on Airway Epithelia.

Authors:  Jin-Ah Park; Jeffrey J Fredberg; Jeffrey M Drazen
Journal:  Physiology (Bethesda)       Date:  2015-07

7.  Interferons modulate mitogen-induced protein synthesis in airway smooth muscle.

Authors:  Elena A Goncharova; Poay N Lim; Amelia Chisolm; Homer W Fogle; Jerome H Taylor; Dmitry A Goncharov; Andrew Eszterhas; Reynold A Panettieri; Vera P Krymskaya
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-04-09       Impact factor: 5.464

8.  Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.

Authors:  Elizabeth L Kramer; Elizabeth M Mushaben; Patricia A Pastura; Thomas H Acciani; Gail H Deutsch; Gurjit K Khurana Hershey; Thomas R Korfhagen; William D Hardie; Jeffrey A Whitsett; Timothy D Le Cras
Journal:  Am J Respir Cell Mol Biol       Date:  2009-02-02       Impact factor: 6.914

9.  Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.

Authors:  Hyun Sil Lee; Allen Myers; Jean Kim
Journal:  Am J Respir Crit Care Med       Date:  2009-09-17       Impact factor: 21.405

10.  TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids.

Authors:  Astrid M Doerner; Bruce L Zuraw
Journal:  Respir Res       Date:  2009-10-27
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