OBJECTIVE: It is known that the placenta acts as an immunological barrier between the mother and fetal "graft" allowing two antigenically different organisms to tolerate one another. Preeclampsia may be considered as a fetal rejection consequent to severe damage at placental endothelial and syncytiotrophoblast level. In order to verify this placental barrier damage we undertook the present study by electron microscopy. STUDY DESIGN: 14 placentae from preeclaptic women, and the same number of placentae from healthy controls were examined. RESULTS: The results showed that endothelial cells from preeclamptic placentae express various and severe alterations, consisting of swollen and bulbous cytoplasm, degenerated inter-endothelial junctions with consequent crossing of fetal blood cells outside the vessels. CONCLUSIONS: These lesions could be the ultrastructural evidence of the placental barrier breakage leading to rejective reaction we presumed to be basis of preeclampsia.
OBJECTIVE: It is known that the placenta acts as an immunological barrier between the mother and fetal "graft" allowing two antigenically different organisms to tolerate one another. Preeclampsia may be considered as a fetal rejection consequent to severe damage at placental endothelial and syncytiotrophoblast level. In order to verify this placental barrier damage we undertook the present study by electron microscopy. STUDY DESIGN: 14 placentae from preeclaptic women, and the same number of placentae from healthy controls were examined. RESULTS: The results showed that endothelial cells from preeclamptic placentae express various and severe alterations, consisting of swollen and bulbous cytoplasm, degenerated inter-endothelial junctions with consequent crossing of fetal blood cells outside the vessels. CONCLUSIONS: These lesions could be the ultrastructural evidence of the placental barrier breakage leading to rejective reaction we presumed to be basis of preeclampsia.
Authors: Andrea Balogh; Judit Pozsgay; János Matkó; Zhong Dong; Chong Jai Kim; Tibor Várkonyi; Marei Sammar; János Rigó; Hamutal Meiri; Roberto Romero; Zoltán Papp; Nándor Gábor Than Journal: Am J Obstet Gynecol Date: 2011-03-22 Impact factor: 8.661
Authors: Emmett E Whitaker; Abbie C Johnson; Justin E Miller; Devon P Lindner; Marilyn J Cipolla Journal: Mech Ageing Dev Date: 2021-04-14 Impact factor: 5.498
Authors: Åsa Nääv; Lena Erlandsson; Josefin Axelsson; Irene Larsson; Martin Johansson; Lena Wester-Rosenlöf; Matthias Mörgelin; Vera Casslén; Magnus Gram; Bo Åkerström; Stefan R Hansson Journal: PLoS One Date: 2015-05-08 Impact factor: 3.240